Journal of Pediatric Surgery
Volume 36, Issue 7 , Pages 985-994 , July 2001

Mechanisms for the development of esophageal atresia

References 

  1. Thompson DJ, Molello JA, Strebing RJ, et al.  Teratogenicity of adriamycin and daunomycin in the rat and rabbit. Teratology. 1978;17:151–157
  2. Diez-Pardo JA, Baoquan Q, Navarro C, et al.  A new rodent experimental model of esophageal atresia and tracheoesophageal fistula: Preliminary report. J Pediatr Surg. 1996;31:498–502
  3. Possogel AK, Diez-Pardo JA, Morales C, et al.  Embryology of esophageal atresia in the adriamycin rat model. J Pediatr Surg. 1998;33:606–612
  4. Qi BQ, Diez-Pardo JA, Navarro C, et al.  Narrowing the embryonic window of the Adriamycin-induced fetal rat model of oesophageal atresia and tracheooesophageal fistula. Pediatr Surg Int. 1996;11:444–447
  5. Kotsios C, Merei J, Hutson JM, et al.  Skeletal anomalies in the adriamycin- exposed prenatal rat: a model for VATER association. J Orthopaed Res. 1998;16:50–53
  6. Merei J, Kotsios C, Hutson JM, et al.  Histopathologic study of esophageal atresia and tracheoesophageal fistula in an animal model. J Pediatr Surg. 1997;32:12–14
  7. Qi BQ, Merei J, Farmer P, et al.  Cardiovascular malformations in rat fetuses with oesophageal atresia and tracheo-oesophageal fistula induced by adriamycin [see comments]. Pediatr Surg Int. 1997;12:556–564
  8. Xia H, Otten C, Migliazza L, et al.  Tracheobronchial malformations in experimental esophageal atresia. J Pediatr Surg. 1999;34:536–539
  9. Qi BQ, Beasley SW. Communicating bronchopulmonary foregut malformations in the adriamycin-induced rat model of oesophageal atresia. Aust N Z J Surg. 1999;69:56–59
  10. Qi BQ, Merei J, Farmer P, et al.  Tracheomalacia with esophageal atresia and tracheoesophageal fistula in fetal rats. J Pediatr Surg. 1997;32:1575–1579
  11. Qi BQ, Merei J, Farmer P, et al.  The vagus and recurrent laryngeal nerves in the rodent experimental model of esophageal atresia. J Pediatr Surg. 1997;32:1580–1586
  12. Qi BQ, Beasley S. Relationship of the notochord to foregut development in the fetal rat model of esophageal atresia. J Pediatr Surg. 1999;34:1593–1598
  13. Cheng W, Bishop AE, Spitz L, et al.  Abnormal enteric nerve morphology in atretic esophagus of fetal rats with adriamycin-induced esophageal atresia [see comments]. Pediatr Surg Int. 1999;15:8–10
  14. Merei JM, Farmer P, Hasthorpe S, et al.  Timing and embryology of esophageal atresia and tracheo-esophageal fistula. Anatomical Record. 1997;249:240–248
  15. Orford JE, P Manglick, Cass DT. Apoptosis in the embryogenesis of oesophageal atresia in the rat model of VATER Association. Aust Assoc Paediatr Surg ASM. 1999; (abstr)
  16. Merei J, Hasthorpe S, Farmer P, et al.  Relationship between esophageal atresia with tracheoesophageal fistula and vertebral anomalies in mammalian embryos. J Pediatr Surg. 1998;33:58–63
  17. Orford JE, Cass DT. Dose response relationship between adriamycin and birth defects in a rat model of VATER association. J Pediatr Surg. 1999;34:392–398
  18. Possoegel AK, Diez-Pardo JA, Morales C, et al.  Notochord involvement in experimental esophageal atresia. Pediatr Surg Int. 1999;15:201–205
  19. Tewey KM, Chen GL, Nelson EM, et al.  Intercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II. J Bio Chemi. 1984;259:9182–9187
  20. Tewey KM, Rowe TC, Yang L, et al.  Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II. Science. 1984;226:466–468
  21. Young RC, Ozols RF, Myers CE. The anthracycline antineoplastic drugs. N Engl J Med. 1981;305:139–153
  22. Blum RH, Carter SK. Adriamycin: A new anticancer drug with significant clinical activity. Ann Int Med. 1974;80:249–259
  23. Schwartz HS. DNA breaks in P-288 tumor cells in mice after treatment. Research Communications in Chemical Pathology and Pharmacology. 1975;10:51–64
  24. Muller I, Niethammer D, Bruchelt G. Anthracycline-derived chemotherapeutics in apoptosis and free radical cytotoxicity. Inter J Mole Medic. 1998;1:491–494
  25. Brill A, Torchinsky A, Carp H, et al.  The role of apoptosis in normal and abnormal embryonic development. J Assist Reproduc Genet. 1999;16:512–519
  26. Jurand A. Some aspects of the development of the notochord in mouse embryos. J Embryol Exp Morphol. 1974;32:1–33
  27. Gerlach C, Sakkab DY, Scholzen T, et al.  Ki-67 expression during rat liver regeneration after partial hepatectomy. Hepatology. 1997;26:573–578
  28. Ben-Sasson SA, Sherman Y, Gavrieli Y. Identification of dying cells—in situ staining. Methods in Cell Biology. 1995;46:29–39
  29. Wilkinson DG. The theory and practice of in situ hybridization. In:  Wilkinson DG editors. In Situ Hybridization: A Practical Approach. New York, NY: Oxford; 1992;p. 13
  30. Beasley SW, Qi BQ. The role of apoptosis in the separation of the trachea and esophagus. PAPS. 1998;50: (abstr)
  31. Zhou B, Hutson JM, Farmer PJ, et al.  Apoptosis in tracheoesophageal embryogenesis in rat embryos with or without adriamycin treatment. J Pediatr Surg. 1999;34:872–875
  32. Chiang C, Litingtung Y, Lee E, et al.  Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature. 1996;383:407–413
  33. Roberts DJ, Johnson RL, Burke AC, et al.  Sonic hedgehog is an endodermal signal inducing Bmp-4 and Hox genes during induction and regionalization of the chick hindgut. Development. 1995;121:3163–3174
  34. Litingtung Y, Lei L, Westphal H, et al.  Sonic hedgehog is essential to foregut development. Nat Gene. 1998;20:58–61
  35. Motoyama J, Liu J, Mo R, et al.  Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus. Nat Gene. 1998;20:54–57
  36. Kim P, Mo R, Hui CC. Murine model of VACTERL syndrome: role of sonic hedgehog transcription factors Gli2 and Gli3. BAPS. 2000;A88; (abstr)
  37. Goh KL, Yang JT, Hynes RO. Mesodermal defects and cranial neural crest apoptosis in alpha5 integrin-null embryos. Development. 1997;124:4309–4319
  38. Filosa S, Rivera-Perez JA, Gomez AP, et al.  Goosecoid and HNF-3beta genetically interact to regulate neural tube patterning during mouse embryogenesis. Development. 1997;124:2843–2854
  39. Bellusci S, Furuta Y, Rush MG, et al.  Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis. Development. 1997;124:53–63
  40. Cann GM, Lee JW, Stockdale FE. Sonic hedgehog enhances somite cell viability and formation of primary slow muscle fibers in avian segmented mesoderm. Anat Embryol. 1999;200:239–252
  41. Buscher D, Bosse B, Heymer J, et al.  Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb development. Mech Dev. 1997;62:175–182
  42. Ingham P. The patched gene in development and cancer. Curr Genet Dev. 1998;8:88–94
  43. Goodrich LV, Johnson RL, Milenkovic L, et al.  Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog. Genes Dev. 1996;10:301–312
  44. Moore KL, Persaud TVN. Formation of the human embryo: The third week. In:  Moore K,  Persaud T editor. The Developing Human: Clinically Oriented Embryology. Philadelphia, PA: Saunders; 1993;p. 53–69
  45. Warren J, Evans K, Carter CO. Offspring of patients with tracheo-oesophageal fistula. J Med Gene. 1979;16:338–340
  46. Orford J, Glasson M, Beasley S, et al.  Oesophageal atresia in twins. Paediatr Surg Int. 2000;16:541–545
  47. Bankier A, Brady J, Myers NA. Epidemiology and genetics. In:  Beasley SW,  Myers NA,  Auldist AW editor. Oesophageal Atresia. Chapman Hall Medical; 1991;p. 19–29
  48. David TJ, O'Callaghan SE. Twinning and oesophageal atresia. Arch Dis Child. 1974;49:660–662
  49. Harris J, Kallen B, Robert E. Descriptive epidemiology of alimentary tract atresia. Teratology. 1995;52:15–29
  50. Heydanus R, Santema JG, Stewart PA, et al.  Preterm delivery rate and fetal outcome in structurally affected twin pregnancies: a retrospective matched control study. Prenatal Diagnosis. 1993;13:155–162

 J.O. was supported by a NHMRC Medical Postgraduate Scholarship, and P.P.L.T. is a NHMRC Principal Research Fellow.

☆☆ Address reprint requests to J.E. Orford, Surgical Services Department, Princess Margaret Hospital for Children, Roberts Rd, Subiaco, Western Australia, 6008.

PII: S0022-3468(01)60238-0

doi: 10.1053/jpsu.2001.24722

Journal of Pediatric Surgery
Volume 36, Issue 7 , Pages 985-994 , July 2001