Journal of Pediatric Surgery
Volume 38, Issue 1 , Pages 73-77 , January 2003

Immunocolocalization of the heme oxygenase-2 and interstitial cells of Cajal in normal and aganglionic colon

Presented at the 49th Annual Congress of the British Association of Paediatric Surgeons, Cambridge, England, July 23-26, 2002.

  • Image Result

    Differences in the distribution of c-kit–immunopositive ICCs in the normal and HD colon. (A) ICCs-MY formed a dense network surrounding the myenteric plexus in the normal colon (other arrows). ICCs-IM

    Differences in the distribution of c-kit–immunopositive ICCs in the normal and HD colon. (A) ICCs-MY formed a dense network surrounding the myenteric plexus in the normal colon (other arrows). ICCs-IM in the circular muscle (top arrows) (B) ICCs-MY as a single cells in the transition zone. (C) Lack of ICCs-IM and ICCs-MY in the aganglionic colon.

  • Image Result
    Immunostaining of HO-2 in the normal bowel. (A) HO-2 IR in the ganglion cells in the myenteric plexus (arrow) and in the nerve fibres interconnecting ganglia. (B) HO-2 IR in the submucosal ganglion (a

    Immunostaining of HO-2 in the normal bowel. (A) HO-2 IR in the ganglion cells in the myenteric plexus (arrow) and in the nerve fibres interconnecting ganglia. (B) HO-2 IR in the submucosal ganglion (arrow). (C) HO-2 IR in the endothelial cells in the blood submucosal vessels in the submucosa (arrow).

  • Image Result
    C-kit and HO-2 IR in the circular muscle in the normal colon. (A) C-kit–positive ICCs-IM in the circular muscle (arrows). (B) HO-2 IR in the circular muscle (arrows). (C) Double labelling with c-kit/H

    C-kit and HO-2 IR in the circular muscle in the normal colon. (A) C-kit–positive ICCs-IM in the circular muscle (arrows). (B) HO-2 IR in the circular muscle (arrows). (C) Double labelling with c-kit/HO-2 shows immunocolocalization HO-2 in the ICCs-IM (arrows).

  • Image Result
    C-kit and HO-2 IR in the myentric plexus in the normal colon. (A) C-kit–positive ICCs-MY around ganglia cells in the myenteric plexus (arrows). (B) HO-2 IR in the ganglia cells in the myenteric plexus

    C-kit and HO-2 IR in the myentric plexus in the normal colon. (A) C-kit–positive ICCs-MY around ganglia cells in the myenteric plexus (arrows). (B) HO-2 IR in the ganglia cells in the myenteric plexus (arrows). (C) Double labelling with c-kit/HO-2 shows immunocolocalization HO-2 in the ICCs-MY (arrows).

☆ Address reprint requests to Professor Prem Puri, MS, FRCS, FRCS (Ed), FACS, Director of Research, Children's Research Centre, Our Lady's Hospital for Sick Children, Crumlin, Dublin 12, Ireland.

PII: S0022-3468(02)63022-2

doi: 10.1053/jpsu.2003.50014

Journal of Pediatric Surgery
Volume 38, Issue 1 , Pages 73-77 , January 2003

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