Journal of Pediatric Surgery
Volume 40, Issue 12 , Pages 1861-1864 , December 2005

In utero exposure to mono-n-butyl phthalate impairs insulin-like factor 3 gene expression and the transabdominal phase of testicular descent in fetal rats

References 

  1. Imajima T, Shono T, Zakaria O, et al. Prenatal phthalate causes cryptorchidism postnatally by inducing transabdominal ascent of the testis in fetal rats. J Pediatr Surg. 1997;32:18–21
  2. Mylchreest E, Cattley RC, Foster PMD. Male reproductive tract malformations in rats following gestational and lactational exposure to di8n-butyl9 phthalate: an antiandrogenic mechanism?. Toxicol Sci. 1998;58:350–365
  3. Ema M, Miyawaki E, Hirose A, et al. Decreased anogenital distance and increased incidence of undescended testes in fetuses of rats given monobenzyl phthalate, a major metabolite of butyl benzyl phthalate. Reprod Toxicol. 2003;17:407–412
  4. Gray LE, Ostby J, Furr J, et al. Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP or DOTP, alters sexual differentiation of the male rat. Toxicol Sci. 2000;58:350–365
  5. Hutson JM. A biphasic model for the hormonal control of testicular descent. Lancet. 1985;2:419–421
  6. Shono T, Ramm-Anderson S, Hutson JM. Transabdominal testicular descent is really ovarian ascent. J Urol. 1994;152:781–784
  7. Shono T, Ram-Anderson S, Goh DW, et al. The effect of flutamide on testicular descent in rats examined by scanning electron microscopy. J Pediatr Surg. 1994;29:839–844
  8. Hutson JM, Hasthorpe S, Heynes CF. Anatomical and functional aspects of testicular descent and cryptorchidism. Endocr Rev. 1997;18:259–280
  9. Fentener van Vlissingen JM, van Zoelen EJ, Ursem PJ, et al. In vitro model of the first phase of testicular descent: identification of a low molecular weight factor from fetal testis involved in proliferation of gubernaculum testis cells and distinct from specified polypeptide growth factors and fetal gonadal hormones. Endocrinology. 1988;123:2868–2877
  10. Zimmermann S, Steding G, Emmen JM, et al. Targeted disruption of the INSL3 gene causes bilateral cryptorchidism. Mol Endocrinol. 1999;13:681–691
  11. Nef S, Parada LF. Cryptorchidism in mice mutant for INSL3. Nat Genet. 1999;22:295–299
  12. Zimmermann S, Schottler P, Engel W, et al. Mouse Leydig insulin-like (Ley I-L) gene: structure and expression during testis and ovary development. Mol Reprod Dev. 1997;47:30–38
  13. Wilson VS, Lambright C, Furr J, et al. Phthalate ester-induced gubernacular lesions are associated with reduced insl3 gene expression in the fetal rat testis. Toxicol Lett. 2004;146:207–215
  14. Mayer FL, Stalling DL, Johnson JL. Phthalate esters as environmental contaminants. Nature. 1972;238:411–413
  15. Otake T, Yoshinaga J, Yanagiwa Y. Exposure to phthalate esters from indoor environment. J Expo Anal Environ Epidemiol. 2004;14:524–528
  16. Shono T, Kai H, Suita S, et al. Time-specific effects of mono-n-butyl phthalate on the transabdominal descent of the testis in rat fetuses. BJU Int. 2000;86:121–126
  17. Srivastava S, Srivastava SP. Effect of di (2-ethylhexyl) phthalate on 17 beta-hydroxysteroid dehydrogenase activity in testis of rat. Toxicol Lett. 1991;57:235–239
  18. Mylchreest E, Sar M, Cattley RC, et al. Disruption of androgen-regulated male reproductive development by di (n-butyl) phthalate during late gestation in rats is different from flutamide. Toxicol Appl Pharmacol. 1999;156:91–95
  19. Adham IM, Steding G, Thamm T, et al. The overexpression of the Insl3 in female mice causes descent of the ovaries. Mol Endocrinol. 2002;16:244–252
  20. Kubota Y, Nef S, Farmer PJ, et al. Leydig insulin-like hormone, gubernacular development and testicular descent. J Urol. 2001;165:1673–1675
  21. Boockfor FR, Fullbright G, Büllesbach EE, et al. Relaxin-like factor (RLF) serum concentrations and gubernaculum RLF receptor display in relation to pre-and neonatal development of rats. Reproduction. 2001;122:899–906

 Presented at the 38th Annual Meeting of the Pacific Association of Pediatric Surgeons, May 22-26, 2005, Vancouver, Canada.

PII: S0022-3468(05)00685-8

doi: 10.1016/j.jpedsurg.2005.08.027

Journal of Pediatric Surgery
Volume 40, Issue 12 , Pages 1861-1864 , December 2005

Article Tools

* Image Usage & Resolution