Journal of Pediatric Surgery
Volume 40, Issue 12 , Pages 1865-1868 , December 2005

The role of hepatocyte growth factor in the humoral regulation of inguinal hernia closure

  • Alvin Y.S. Ting

      Affiliations

    • Department of Paediatrics, University of Melbourne, Melbourne 3050, Australia
    • ,
  • Jenny Huynh

      Affiliations

    • Department of Paediatrics, University of Melbourne, Melbourne 3050, Australia
    • ,
  • Pamela Farmer

      Affiliations

    • Murdoch Children's Research Institute, Melbourne 3050, Australia
    • Department of General Surgery, Royal Children's Hospital, Parkville, Victoria 3052, Australia
    • ,
  • Eric X.Z. Yong

      Affiliations

    • Department of Paediatrics, University of Melbourne, Melbourne 3050, Australia
    • ,
  • Suzanne Hasthorpe

      Affiliations

    • Department of Paediatrics, University of Melbourne, Melbourne 3050, Australia
    • Murdoch Children's Research Institute, Melbourne 3050, Australia
    • Department of General Surgery, Royal Children's Hospital, Parkville, Victoria 3052, Australia
    • ,
  • Amanda Fosang

      Affiliations

    • Department of Paediatrics, University of Melbourne, Melbourne 3050, Australia
    • Murdoch Children's Research Institute, Melbourne 3050, Australia
    • ,
  • Sebastian King

      Affiliations

    • Department of Paediatrics, University of Melbourne, Melbourne 3050, Australia
    • Murdoch Children's Research Institute, Melbourne 3050, Australia
    • Department of General Surgery, Royal Children's Hospital, Parkville, Victoria 3052, Australia
    • ,
  • Aniruddha Deshpande

      Affiliations

    • Department of General Surgery, Royal Children's Hospital, Parkville, Victoria 3052, Australia
    • ,
  • John Hutson

      Affiliations

    • Department of Paediatrics, University of Melbourne, Melbourne 3050, Australia
    • Murdoch Children's Research Institute, Melbourne 3050, Australia
    • Department of General Surgery, Royal Children's Hospital, Parkville, Victoria 3052, Australia
    • Corresponding Author InformationCorresponding author. Department of General Surgery, Royal Children's Hospital, Parkville, Victoria 3052, Australia. Tel.: +61 3 93455805; fax: +61 3 93457997.

References 

  1. Hutson JM, Hasthorpe S. Testicular descent and cryptorchidism: the state of the art in 2004. J Pediatr Surg. 2005;40:297–302
  2. Hunter RH. The etiology of congenital inguinal hernia and abnormally placed testes. Br J Surg. 1926;15:125–130
  3. Wells L. Descent of the testis: anatomical and hormonal considerations. Surgery. 1943;14:436–472
  4. Clarnette TD, Hutson JM. The development and closure of the processus vaginalis. Hernia. 1999;3:97–102
  5. Clarnette TD, Hutson JM. The genitofemoral nerve may link testicular inguinoscrotal descent with congenital inguinal hernia. ANZ J Surg. 1996;66:612–617
  6. Husmann DA. Cryptorchidism—problems extrapolating experimental animal data to the clinical undescended testicle. J Urol. 1998;159:1029–1030
  7. Hutson JM, Albano FR, Paxton G, et al. In vitro fusion of human inguinal hernia with associated epithelial transformation. Cells Tissues Organs. 2000;166:249–258
  8. Fitchett JE, Hay ED. Medial edge epithelium transforms to mesenchyme after embryonic palatal shelves fuse. Dev Biol. 1989;131:455–474
  9. Singh-Kaw P, Zarnegar R, Siegfried JM. Stimulatory effects of hepatocyte growth factor on normal and neoplastic human bronchial epithelial cells. Am J Physiol. 1995;268:L1012–L1020
  10. Takahashi M, Ota S, Shimada T, et al. Hepatocyte growth factor is the most potent endogenous stimulant of rabbit gastric epithelial cell proliferation and migration in primary culture. J Clin Invest. 1995;95:1994–2003
  11. Gohji K, Nomi M, Niitani Y, et al. Independent prognostic value of serum hepatocyte growth factor in bladder cancer. J Clin Oncol. 2000;18:2963–2971
  12. Liu Y, Tolbert EM, Lin L, et al. Up-regulation of hepatocyte growth factor receptor: an amplification and targeting mechanism for hepatocyte growth factor action in acute renal failure. Kidney Int. 1999;55:442–453
  13. Stoker M, Gherardi E, Perryman M, et al. Scatter factor is a fibroblast-derived modulator of epithelial cell mobility. Nature. 1987;327:239–242
  14. Skibinski G, Skibinska A, James K. The role of hepatocyte growth factor and its receptor c-met in interactions between lymphocytes and stromal cells in secondary human lymphoid organs. Immunology. 2001;102:506–514
  15. Sugita Y, Uemura S, Hasthorpe S, et al. Calcitonin gene–related peptide–immunoreactive nerve fibres and receptors in the human processus vaginalis. Hernia. 1999;3:113–116
  16. Zhu Y, Hojo Y, Ikeda U, et al. Production of hepatocyte growth factor during acute myocardial infarction. Heart. 2000;83:450–455
  17. Rampino T, Cancarini G, Gregorini M, et al. Hepatocyte growth factor/scatter factor released during peritonitis is active on mesothelial cells. Am J Pathol. 2001;159:1275–1285
  18. Cook B, Hasthorpe S, Hutson JM. Fusion of childhood inguinal hernia induced by HGF and CGRP via an epithelial transition. J Pediatr Surg. 2000;35:77–81

 Presented at the 38th Annual Meeting of the Pacific Association of Pediatric Surgeons, May 22-26, 2005, Vancouver, Canada.

PII: S0022-3468(05)00686-X

doi: 10.1016/j.jpedsurg.2005.08.044

Journal of Pediatric Surgery
Volume 40, Issue 12 , Pages 1865-1868 , December 2005

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