Journal of Pediatric Surgery
Volume 43, Issue 3 , Pages 443-446 , March 2008

Absence of motilin gene mutations in infantile hypertrophic pyloric stenosis

  • Anna Svenningsson

      Affiliations

    • Department of Molecular Medicine and Surgery, Karolinska Institutet, 171 76 Stockholm, Sweden
    • Division of Pediatric Surgery, Astrid Lindgren's Hospital, Karolinska University Hospital, 171 76 Stockholm, Sweden
    • ,
  • Kristina Lagerstedt

      Affiliations

    • Department of Molecular Medicine and Surgery, Karolinska Institutet, 171 76 Stockholm, Sweden
    • ,
  • Mir Davood Omrani

      Affiliations

    • Department of Molecular Medicine and Surgery, Karolinska Institutet, 171 76 Stockholm, Sweden
    • ,
  • Agneta Nordenskjöld

      Affiliations

    • Department of Molecular Medicine and Surgery, Karolinska Institutet, 171 76 Stockholm, Sweden
    • Division of Pediatric Surgery, Astrid Lindgren's Hospital, Karolinska University Hospital, 171 76 Stockholm, Sweden
    • Corresponding Author InformationCorresponding author. CMM L8:02, Karolinska University Hospital, 171 76 Stockholm, Sweden. Tel.: +46 8 517 764 08; fax: +46 8 517 736 20.

References 

  1. Jedd MB, Melton JI, Griffin MR, et al. Factors associated with infantile hypertrophic pyloric stenosis. Am J Dis Child. 1988;142:334–337
  2. Stang H. Pyloric stenosis associated with erythromycin ingested through breastmilk. Minn Med 1986;69:669-70, 682.
  3. Fried K, Aviv S, Nisenbaum C. Probable autosomal dominant infantile pyloric stenosis in a large kindred. Clin Genet. 1981;20(5):328–330
  4. Soderhall C, Nordenskjold A. Neuronal nitric oxide synthase, nNOS, is not linked to infantile hypertrophic pyloric stenosis in three families. Clin Genet. 1998;53(5):421–422
  5. Capon F, Reece A, Ravindrarajah R, et al. Linkage of monogenic infantile hypertrophic pyloric stenosis to chromosome 16p12-p13 and evidence for genetic heterogeneity. Am J Hum Genet. 2006;79(2):378–382
  6. Carter CO, Evans KA. Inheritance of congenital pyloric stenosis. J Med Genet. 1969;6:233–254
  7. Mitchell LE, Risch N. The genetics of infantile hypertrophic pyloric stenosis: a reanalysis. Am J Dis Child. 1993;147:1203–1211
  8. Chakraborty R. The inheritance of pyloric stenosis explained by a multifactorial threshold model with sex dimorphism for liability. Genet Epidemiol. 1986;3:1–15
  9. Honein MA, Paulozzi LJ, Himelright IM, et al. Infantile hypertrophic pyloric stenosis after pertussis prophylaxis with erythromycin: a case review and cohort study. Lancet. 1999;354:2101–2105
  10. Cooper WO, Griffin MR, Arbogast P, et al. Very early exposure to erythromycin and infantile hypertrophic pyloric stenosis. Arch Pediatr Adolesc Med. 2002;156:647–650
  11. Mahon BE, Rosenman MB, Kleiman MB. Maternal and infant use of erythromycin and other macrolide antibiotics as risk factors for infantile hypertrophic pyloric stenosis. J Pediatr. 2001;139(3):380–384
  12. Peeters T, Matthijs G, Depoortere I, et al. Erythromycin is a motilin receptor agonist. Am J Physiol. 1989;257:G470–G474
  13. Jadcherla S, Klee G, Berseth C. Regulation of migrating motor complexes by motilin and pancreatic polypeptide in human infants. Pediatr Res. 1997;42:365–369
  14. Sarna SK, Soergel KH, Koch TR, et al. Gastrointestinal motor effects of erythromycin in human. Gastroenterology. 1991;101:1488–1496
  15. Tack J, Janssens J, Vantrappen G, et al. Effect of erythromycin on gastric motility in controls and diabetic gastroparesis. Gastroenterology. 1992;103:72–79
  16. Kawamura O, Sekiguchi T, Kusano M, et al. Effect of erythromycin on interdigestive gastrointestinal contractile activity and plasma concentration in humans. Dig Dis Sci. 1993;38:870–876
  17. Pearse A, Polak J, Bloom S, et al. Enterochromaffin cells of the mammalian small intestine as the source of motilin. Virchows Arch B Cell Pathol. 1974;16:111–120
  18. Bormans V, Peeters TL, Janssens J, et al. In man, only activity fronts that originate in the stomach correlate with motilin peaks. Scand J Gastroenterol. 1987;22:781–784
  19. Vantrappen G, Janssens J, Peeters TL, et al. Motilin and the interdigestive migrating motor complex in man. Dig Dis Sci. 1979;24:497–500
  20. Daikh DI, Douglass JO, Adelman JP. Structure and expression of the human motilin gene. DNA. 1989;8(8):615–621
  21. Seino Y, Tanaka K, Takeda J, et al. Sequence of an intestinal cDNA encoding human motilin precursor. FEBS Lett. 1987;223:74–76
  22. Yano H, Seino Y, Fujita J, et al. Exon-intron organization, expression, and chromosomal localization of the human motilin gene. FEBS Lett. 1989;249:248–252
  23. Liu J, Qiao X, Qian W, et al. Motilin in human milk and its elevated plasma concentration in lactating women. J Gastroenterol Hepatol. 2004;19(10):1187–1191

PII: S0022-3468(07)00816-0

doi: 10.1016/j.jpedsurg.2007.10.006

Journal of Pediatric Surgery
Volume 43, Issue 3 , Pages 443-446 , March 2008

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