Journal of Pediatric Surgery
Volume 44, Issue 10 , Pages 1988-1994 , October 2009

Protective effect of erythropoietin on torsion/detorsion injury in rat model

  • Vedat Bakan

      Affiliations

    • Faculty of Medicine, Department of Pediatric Surgery, Sutcu Imam University, Kahramanmaras 46100, Turkey
    • Corresponding Author InformationCorresponding author. KSÜ Tıp Fakültesi Çocuk Cerrahisi AD Kahramanmaraş, Turkey. Tel.: +90 344 221 23 37; fax: +90 344 221 23 71.
  • ,
  • Harun Çıralık

      Affiliations

    • Faculty of Medicine, Department of Pathology, Sutcu Imam University, Kahramanmaras 46100, Turkey
  • ,
  • Fatma İnanaç Tolun

      Affiliations

    • Faculty of Medicine, Department of Biochemistry, Sutcu Imam University, Kahramanmaras 46100, Turkey
  • ,
  • Yalçın Atlı

      Affiliations

    • Faculty of Medicine, Department of Biochemistry, Sutcu Imam University, Kahramanmaras 46100, Turkey
  • ,
  • Ayhan Mil

      Affiliations

    • Faculty of Medicine, Department of Pediatric Surgery, Sutcu Imam University, Kahramanmaras 46100, Turkey
  • ,
  • Şenol Öztürk

      Affiliations

    • Faculty of Medicine, Department of Pediatric Surgery, Sutcu Imam University, Kahramanmaras 46100, Turkey

Received 21 December 2008 ,Revised 12 February 2009 ,Accepted 13 February 2009.

References 

  1. Adelman S, Benson CD, Hertzler JH. Surgical lesions of the ovary in infancy and childhood. Surg Gynecol Obstet. 1975;141:219–226
  2. Cass DL. Ovarian torsion. Semin Pediatr Surg. 2005;14:86–92
  3. Beaunoyer M, Chapdelaine J, Bouchard S, et al. Asynchronous bilateral ovarian torsion. J Pediatr Surg. 2004;39:746–749
  4. Çelik A, Ergün O, Aldemir H, et al. Long-term results of conservative management of adnexal torsion in children. J Pediatr Surg. 2005;40:704–708
  5. Li C, Jackson RM. Reactive species mechanisms of cellular hypoxi-reoxygenation injury. Am J Physiol (Cell Physiol). 2002;282:227–241
  6. McCord JM. Oxygen-derived free radicals in postischemic tissue injury. N Engl J Med. 1985;312:159–163
  7. Akgür FM, Brown MF, Zibari GB, et al. Role of superoxide in hemorrhagic shock-induced P-selectin expression. Am J Physiol Heart Circ Physiol. 2000;279:791–797
  8. Mori S, Sawada T, Okada T, et al. Erythropoietin and its derivative protect the intestine from severe ischemia/reperfusion injury in the rat. Surgery. 2008;143:556–565
  9. Spandou E, Tsouchnikas I, Karkavelas G, et al. Erythropoietin attenuates renal injury in experimental acute renal failure ischemic/reperfusion model. Nephrol Dial Transplant. 2006;21:330–336
  10. Sepodes B, Maio R, Pinto R, et al. Recombinant human erythropoietin protects the liver from hepatic ischemia-reperfusion injury in the rat. Transplant Int. 2006;19:919–926
  11. Minamino T, Kitakaze M. New therapeutic application of erythropoietin against ischemic heart diseases. J Pharmacol Sci. 2006;101:179–181
  12. Ergur BU, Kıray M, Pekcetin C. Protective effect of erythropoietin pretreatment in testicular ischemia-reperfusion injury in rats. J Pediatr Surg. 2008;43:722–728
  13. Santhanam AV, Katusic ZS. Erythropoietin and cerebral vascular protection: role of nitric oxide. Acta Pharmacol Sin. 2006;27:1389–1394
  14. Jelkmann W. Erythropoietin after a century of research: younger than ever. Eur J Haematol. 2007;78:183–205
  15. Brines M, Cerami A. Discovering erythropoietin's extrahematopoietic functions: biology and clinical promise. Kidney Int. 2006;70:246–250
  16. Jones NM, Bergeron M. Hypoxic preconditioning induces changes in HIF-1 target genes in neonatal rat brain. J Cereb Blood Flow Metab. 2001;21:1105–1114
  17. Bonello S, Zähringer C, BelAiba RS, et al. Reactive oxygen species activate the HIF-1α promoter via a functional NF-κB site. Arterioscler Thromb Vasc Biol. 2007;27:755–761
  18. Chikuma M, Masuda S, Kobayashi T, et al. Tissue-specific regulation of erythropoietin production in the murine kidney, brain, and uterus. Am J Physiol Endocrinol Metab. 2000;279:1242–1248
  19. Jeanes HL, Tabor C, Black D. Oestrogen-mediated cardioprotection following ischaemia and reperfusion is mimicked by an oestrogen receptor (ER) agonist and unaffected by an ERb antagonist. J Endocrinol. 2008;197:493–501
  20. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 1979;95:351–358
  21. Lowry OH, Rosebrough NJ, Farr A. Protein measurement with the folin phenol reagent. J Biol Chem. 1951;193:265–275
  22. Fridovich I. Superoxide dismutase. Adv Enzymol. 1974;41:35–97
  23. Beutler E. Red cell metabolism. In: A Manual of Biochemical Methods. 2nd ed.. New York: Grune and Stratton Company; 1975;p. 261–265
  24. Moshage H, Kok B, Huizenga JR, et al. Nitrite and nitrate determinations in plasma: a critical evaluation. ClinChem. 1995;41:892–896
  25. Cortas NK, Wakid NW. Determination of inorganic nitratein serum and urine by akinetic cadmium reduction method. Clin Chem. 1990;36:1440–1443
  26. Sagsoz N, Kisa U, Apan A. Ischaemia-reperfusion injury of rat ovary and the effects of vitamin C, mannitol and verapamil. Hum Reprod. 2002;17:2972–2976
  27. Taskin O, Birincioglu M, Aydin A, et al. The effects of twisted ischaemic adnexa managed by detorsion on ovarian viability and histology: an ischaemia-reperfusion rodent model. Hum Reprod. 1998;13:2823–2827
  28. Kazez A, Ozel SK, Akpolat N, et al. The efficacy of conservative treatment for late term ovarian torsion. Eur J Pediatr Surg. 2007;17:110–114
  29. Celik O, Turkoz Y, Hascalik S, et al. The protective effect of caffeic acid phenethyl ester on ischemiareperfusion injury in rat ovary. Eur J Obstet Gynecol Reprod Biol. 2004;117:183–188
  30. Kaleli B, Aktan E, Gezer S, et al. Reperfusion injury after detorsion of unilateral ovarian torsion in rabbits. Eur J Obstet Gynecol Reprod Biol. 2003;110:99–101
  31. Paller MS, Hoidal JR, Ferris TF. Oxygen free radical in ischemic acute renal failure in the rat. J Clin Invest. 1984;74:1156–1164
  32. Kumral A, Gonenc S, Acikgoz O, et al. Erythropoietin increases glutathione peroxidase enzyme activity and decreases lipid peroxidation levels in hypoxic-ischemic brain injury in neonatal rats. Biol Neonate. 2005;87:15–18
  33. Nagai A, Nakagawa E, Choi HB, et al. Erythropoietin and erythropoietin receptors in human CNS neurons, astrocytes, microglia, and oligodendrocytes grown in culture. J Neuropathol Exp Neurol. 2001;60:386–392
  34. Van der Vliet A, Eiserich JP, Halliwell B, et al. Formation of reactive nitrogen species during peroxidase-catalyzed oxidation of nitrite. J Biol Chem. 1997;272:7617–7625
  35. Ferdinandy P. Peroxynitrite: just an oxidative/nitrosative stressor or a physiological regulator as well?. Br J Pharmacol. 2006;148:1–3
  36. Ortega Mateo A, de Artinano AA. Nitric noxide reactivity and mechanisms involved in its biological effects. Pharmacol Res. 2000;42:421–427
  37. Marklund SL. Extracellular superoxide dismutase and other superoxide dismutase isoenzymes in tissues from nine mammalian species. Biochem J. 1984;222:649–655
  38. Demchenko IT, Oury TD, Crapo JD, et al. Regulation of the brain's vascular responses to oxygen. Circulation Res. 2002;91:1031–1037
  39. Zelko IN, Folz RJ. Extracellular superoxide dismutase functions as a major repressor of hypoxia-induced erythropoietin gene expression. Endocrinology. 2005;146:332–340
  40. Jung F, Palmer LA, Zhou N, et al. Hypoxic regulation of inducible nitric oxide synthase via hypoxia inducible factor-1 in cardiac myocytes. Circ Res. 2000;86:319–325
  41. Beleslin-Cokic BB, Cokic VP, Yu X, et al. Erythropoietin and hypoxia stimulate erythropoietin receptorand nitric oxide production by endothelial cells. Blood. 2004;104:2073–2080
  42. Santhanam AV, d'Uscio LV, Peterson TE, et al. Activation of endothelial nitric oxide synthase is critical for erythropoietin-induced mobilization of progenitor cells. Peptides. 2008;29:1451–1455
  43. Joyeux-Faure M, Ramond A, Beguin PC, et al. Early pharmacological preconditioning by erythropoietin mediated by inducible NOS and mitochondrial ATP-dependent potassium channels in the rat heart. Fundam Clin Pharmacol. 2006;20:51–56
  44. Sakanaka M, Wen TC, Matsuda S, et al. In vivo evidence that erythropoietin protects neurons from ischemic damage. Proc Natl Acad Sci USA. 1998;95:4635–4640
  45. Masuda S, Kobayashi T, Chikuma M, et al. The oviduct produces erythropoietinin an estrogen- and oxygen-dependent manner. Am J Physiol Endocrinol Metab. 2000;278:1038–1044
  46. Jelkmann W. Molecular biology of erythropoietin. Intern Med. 2004;43:649–659
  47. Mendelsohn ME. Genomic and nongenomic effects of estrogen in the vasculature. Am J Cardiol. 2002;90:3–6
  48. Vilatoba M, Eckstein C, Bilbao G, et al. 7β-Estradiol differentially activates mitogen-activated proteinkinasesand improves survival following reperfusion injury of reducedsizeliver in mice. Transplant Proc. 2005;37:399–403
  49. Xiao X, Liu D, Zheng S, et al. Protective effect ofestrogen on intestinal ischemia-reperfusion injury in pubertal rats. J Pediatr Surg. 2004;39:1828–1831
  50. Hurn PD, Vannucci SJ, Hagberg H. Adult or perinatal brain injury: does sex matter?. Stroke. 2005;36:193–195
  51. Hardee ME, Arcasoy MO, Blackwell KL, et al. Erythropoietin biology in cancer. Clin Cancer Res. 2006;15:332–339
  52. Oelsner G, Bider D, Goldenberg M, et al. Long term follow-up of the twisted ischemic adnexa managed by detorsion. Fertil Steril. 1993;60:976–979
  53. Sowade B, Sowade O, Möcks J, et al. The safety of treatment with recombinant human erythropoietin in clinical use: a review of controlled studies. Int J Mol Med. 1998;355:303–314
  54. Pham Tourreau S, Fattorutto M, Bonnin P, et al. Direct and indirect effects of epoietin alpha in an experimental model of thrombosis and bleeding in the rabbit. Ann Fr Anesth Reanim. 2003;22(10):870–878
  55. Lipsic E, Westenbrink BD, van der Meer P, et al. Low-dose erythropoietin improves cardiac function in experimental heart failure without increasing haematocrit. Eur J Heart Fail. 2008;10:22–29
  56. Singh AK, Szczech L, Tang KL, et al. Correction of anemia with epoetin alfa in chronic kidney disease. N Engl J Med. 2006;355:2085–2098
  57. McGovern PG, Noah R, Koenigsberg R, et al. Adnexal torsion and pulmonary embolism: case report and review of the literature. Obstet Gynecol Surv. 1999;54:601–608

PII: S0022-3468(09)00157-2

doi: 10.1016/j.jpedsurg.2009.02.071

Journal of Pediatric Surgery
Volume 44, Issue 10 , Pages 1988-1994 , October 2009