Journal of Pediatric Surgery
Volume 44, Issue 10 , Pages 1972-1976 , October 2009

Retrospective study of the surgical management and outcome of nonrhabdomyosarcoma soft tissue sarcomas of the groin and axilla in children

  • Gideon Karplus

      Affiliations

    • Department of Surgery, St Jude Children's Research Hospital, Memphis, TN 38105, USA
    • ,
  • Matthew J. Krasin

      Affiliations

    • Department of Radiological Sciences, St Jude Children's Research Hospital, Memphis, TN 38105, USA
    • ,
  • Carlos Rodriguez-Galindo

      Affiliations

    • Department of Oncology, St Jude Children's Research Hospital, Memphis, TN 38105, USA
    • Department of Pediatrics, University of Tennessee School of Medicine, Memphis, TN 38105, USA
    • ,
  • Beth McCarville

      Affiliations

    • Department of Radiological Sciences, St Jude Children's Research Hospital, Memphis, TN 38105, USA
    • ,
  • Jesse Jenkins

      Affiliations

    • Department of Pathology, St Jude Children's Research Hospital, Memphis, TN 38105, USA
    • ,
  • Bhaskar Rao

      Affiliations

    • Department of Surgery, St Jude Children's Research Hospital, Memphis, TN 38105, USA
    • Department of International Outreach, St Jude Children's Research Hospital, Memphis, TN 38105, USA
    • ,
  • George Spyridis

      Affiliations

    • Department of Surgery, St Jude Children's Research Hospital, Memphis, TN 38105, USA
    • ,
  • Sheri L. Spunt

      Affiliations

    • Department of Oncology, St Jude Children's Research Hospital, Memphis, TN 38105, USA
    • Department of Pediatrics, University of Tennessee School of Medicine, Memphis, TN 38105, USA
    • Corresponding Author InformationDepartment of Oncology, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA. Corresponding author. Tel.: +1 901 595 3984; fax: +1 901 521 9005.

Received 11 November 2008 ,Revised 22 February 2009 ,Accepted 25 February 2009.

References 

  1. Ries L, Smith M, Gurney J, et al. Cancer Incidence and Survival among Children and Adolescents: United States SEER Program 1975-1995, National Cancer Institute, SEER Program. 1999;[Bethesda, NIH Pub. No. 99-4649]
  2. Meyer WH, Spunt SL. Soft tissue sarcomas of childhood. Cancer Treat Rev. 2004;30:269–280
  3. Spunt SL, Pappo AS. Childhood nonrhabdomyosarcoma soft tissue sarcomas are not adult-type tumors. J Clin Oncol. 2006;24:1958–1959[author reply 1959-1960]
  4. Pappo AS, Devidas M, Jenkins J, et al. Phase II trial of neoadjuvant vincristine, ifosfamide, and doxorubicin with granulocyte colony-stimulating factor support in children and adolescents with advanced-stage nonrhabdomyosarcomatous soft tissue sarcomas: a Pediatric Oncology Group Study. J Clin Oncol. 2005;23:4031–4038
  5. Pratt CB, Maurer HM, Gieser P, et al. Treatment of unresectable or metastatic pediatric soft tissue sarcomas with surgery, irradiation, and chemotherapy: a Pediatric Oncology Group study. Med Pediatr Oncol. 1998;30:201–209
  6. Pratt CB, Pappo AS, Gieser P, et al. Role of adjuvant chemotherapy in the treatment of surgically resected pediatric nonrhabdomyosarcomatous soft tissue sarcomas: a Pediatric Oncology Group Study. J Clin Oncol. 1999;17:1219
  7. Carli M, Ferrari A, Mattke A, et al. Pediatric malignant peripheral nerve sheath tumor: the Italian and German soft tissue sarcoma cooperative group. J Clin Oncol. 2005;23:8422–8430
  8. Cecchetto G, Alaggio R, Dall'Igna P, et al. Localized unresectable non-rhabdo soft tissue sarcomas of the extremities in pediatric age: results from the Italian studies. Cancer. 2005;104:2006–2012
  9. Ferrari A, Bisogno G, Alaggio R, et al. Synovial sarcoma of children and adolescents: the prognostic role of axial sites. Eur J Cancer. 2008;44:1202–1209
  10. Kepka L, DeLaney TF, Suit HD, et al. Results of radiation therapy for unresected soft-tissue sarcomas. Int J Radiat Oncol Biol Phys. 2005;63:852–859
  11. Delaney TF, Kepka L, Goldberg SI, et al. Radiation therapy for control of soft-tissue sarcomas resected with positive margins. Int J Radiat Oncol Biol Phys. 2007;67:1460–1469
  12. Kraybill WG, Harris J, Spiro IJ, et al. Phase II study of neoadjuvant chemotherapy and radiation therapy in the management of high-risk, high-grade, soft tissue sarcomas of the extremities and body wall: Radiation Therapy Oncology Group Trial 9514. J Clin Oncol. 2006;24:619–625
  13. Bramwell VH. Adjuvant chemotherapy for adult soft tissue sarcoma: is there a standard of care. J Clin Oncol. 2001;19:1235–1237
  14. Ferrari A, Casanova M, Collini P, et al. Adult-type soft tissue sarcomas in pediatric-age patients: experience at the Istituto Nazionale Tumori in Milan. J Clin Oncol. 2005;23:4021–4030
  15. Pappo AS, Rao BN, Jenkins JJ, et al. Metastatic nonrhabdomyosarcomatous soft-tissue sarcomas in children and adolescents: the St Jude Children's Research Hospital experience. Med Pediatr Oncol. 1999;33:76–82
  16. Spunt SL, Hill DA, Motosue AM, et al. Clinical features and outcome of initially unresected nonmetastatic pediatric nonrhabdomyosarcoma soft tissue sarcoma. J Clin Oncol. 2002;20:3225–3235
  17. Spunt SL, Poquette CA, Hurt YS, et al. Prognostic factors for children and adolescents with surgically resected nonrhabdomyosarcoma soft tissue sarcoma: an analysis of 121 patients treated at St Jude Children's Research Hospital. J Clin Oncol. 1999;17:3697–3705
  18. Neville HL, Andrassy RJ, Lobe TE, et al. Preoperative staging, prognostic factors, and outcome for extremity rhabdomyosarcoma: a preliminary report from the Intergroup Rhabdomyosarcoma Study IV (1991-1997). J Pediatr Surg. 2000;35:317–321
  19. Trovik CS. Local recurrence of soft tissue sarcoma. A Scandinavian Sarcoma Group Project. Acta Orthop Scand Suppl. 2001;72:1–31
  20. Ghert MA, Abudu A, Driver N, et al. The indications for and the prognostic significance of amputation as the primary surgical procedure for localized soft tissue sarcoma of the extremity. Ann Surg Oncol. 2005;12:10–17
  21. Greene F, Page D, Fleming I, et al. AJCC Cancer Staging Handbook. New York: Springer-Verlag; 2002;
  22. Parham DM, Webber BL, Jenkins JJ, et al. Nonrhabdomyosarcomatous soft tissue sarcomas of childhood: formulation of a simplified system for grading. Mod Pathol. 1995;8:705–710
  23. Baldini EH, Goldberg J, Jenner C, et al. Long-term outcomes after function-sparing surgery without radiotherapy for soft tissue sarcoma of the extremities and trunk. J Clin Oncol. 1999;17:3252–3259
  24. Rydholm A. Surgery without radiotherapy in soft tissue sarcoma. Acta Orthop Scand. 1997;(Suppl 273):117–119
  25. Czauderna P. Role of surgery in the management of soft tissue tumors. Future Oncol. 2006;2:667–673
  26. Fong Y, Coit DG, Woodruff JM, et al. Lymph node metastasis from soft tissue sarcoma in adults. Analysis of data from a prospective database of 1772 sarcoma patients. Ann Surg. 1993;217:72–77

PII: S0022-3468(09)00200-0

doi: 10.1016/j.jpedsurg.2009.02.052

Journal of Pediatric Surgery
Volume 44, Issue 10 , Pages 1972-1976 , October 2009

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