Journal of Pediatric Surgery
Volume 44, Issue 10 , Pages 1938-1941 , October 2009

Pepsin measured in induced sputum—a test for pulmonary aspiration in children?

  • Evelyn Ervine

      Affiliations

    • Respiratory Research Group, Queen’s University Belfast, Northern Ireland, UK
    • Corresponding Author InformationCorresponding author. Department of Pediatric Surgery, Royal Belfast Hospital for Sick Children, BT12 6BE Belfast, UK. Tel.: +44 0 2890632004.
    • ,
  • Cyril McMaster

      Affiliations

    • Clinical Biochemistry, Center for Population Studies, Queen’s University Belfast, Northern Ireland, UK
    • ,
  • William McCallion

      Affiliations

    • Department of Pediatric Surgery, Royal Belfast Hospital for Sick Children, Belfast, Northern Ireland, UK
    • ,
  • Michael D. Shields

      Affiliations

    • Respiratory Research Group, Queen’s University Belfast, Northern Ireland, UK
    • Royal Belfast Hospital for Sick Children, Belfast, Northern Ireland, UK

Received 12 November 2008 ,Revised 26 February 2009 ,Accepted 3 March 2009.

References 

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  15. Kim TH, Lee KJ, Yeo M, et al. Pepsin detection in the sputum/saliva for the diagnosis of gastroesophageal reflux disease in patients with clinically suspected atypical gastroesophageal reflux disease symptoms. Digestion. 2008;77(3-4):201–206
  16. Potluri S, Friedenberg F, Parkman HP, et al. Comparison of a salivary/sputum pepsin assay with 24-hour esophageal pH monitoring for detection of gastric reflux into the proximal esophagus, oropharynx, and lung. Dig Dis Sci. 2003;48(9):1813–1817
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☆ Royal Belfast Hospital for Sick Children Research Fellowship grant. Northern Ireland Chest Heart Stroke Association provided funding for the initial development of the pepsin assays.

PII: S0022-3468(09)00237-1

doi: 10.1016/j.jpedsurg.2009.03.020

Journal of Pediatric Surgery
Volume 44, Issue 10 , Pages 1938-1941 , October 2009

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