« Previous
Next »
Journal of Pediatric Surgery
Volume 45, Issue 3
, Pages 483-489
, March 2010
Activated protein C reduces intestinal injury in an experimental model of necrotizing enterocolitis
References
- . Cellular regulation of the protein C pathway. Semin Cell Biol. 1995;6:259–268
- Endothelial cell protein C receptor plays an important role in protein C activation in vivo. Blood. 2001;97:1685–1688
- . The inhibition of blood coagulation by activated Protein C through the selective inactivation of activated Factor V. Biochim Biophys Acta. 1979;571:333–342
- . Activated protein C: potential therapy for severe sepsis, thrombosis, and stroke. Semin Hematol. 2002;39:197–205
- Activated protein C reduces the ischemia/reperfusion-induced spinal cord injury in rats by inhibiting neutrophil activation. Ann Surg. 2000;232:272–280
- Activated protein C reduces ischemia/reperfusion-induced renal injury in rats by inhibiting leukocyte activation. Blood. 2000;95:3781–3787
- Inhibition of coagulation and inflammation by activated protein C or antithrombin reduces intestinal ischemia/reperfusion injury in rats. Crit Care Med. 2004;32:1375–1383
- Anti-inflammatory, antithrombotic, and neuroprotective effects of activated protein C in a murine model of focal ischemic stroke. Circulation. 2001;103:1799–1805
- Activated protein C attenuates acute ischaemia reperfusion injury in skeletal muscle. J Orthop Res. 2005;23:1454–1459
- Beyond sepsis: activated protein C and ischemia-reperfusion injury. Crit Care Med. 2004;32:309–312
- . Necrotising enterocolitis. Lancet. 2006;368:1271–1283
- The role of epithelial Toll-like receptor signaling in the pathogenesis of intestinal inflammation. J Leukoc Biol. 2008;83:493–498
- . Necrotizing enterocolitis. Curr Opin Pediatr. 1998;10:123–130
- . Animal models to study neonatal nutrition in humans. Curr Opin Clin Nutr Metab Care. 2008;11:601–606
- The epidemiology of necrotizing enterocolitis mortality in the United States. Am J Public Health. 1997;87:2026–2031
- . Gut dysfunction in critically ill patients: a review of the literature. Am J Crit Care. 1997;6:204–209
- . Intestinal mucosal injury in critically ill surgical patients: preliminary observations. Am Surg. 1999;65:19–21
- Effects of activated protein C on neonatal hypoxic ischemic brain injury. Brain Res. 2008;1210:56–62
- Effect of retinoic acid on oxygen-induced lung in the newborn rat. Pediatr Pulmonol. 2005;39:35–40
- . A model of intestinal ischemia in the neonatal rat utilizing superior mesenteric artery occlusion and intraluminal platelet-activating factor. J Surg Res. 1995;58:724–727
- Erythropoietin protects against necrotizing enterocolitis of newborn rats by the inhibiting nitric oxide formation. Biol Neonate. 2003;84:325–329
- Multiplex bead array assay for detection of 25 soluble cytokines in blister fluid of patients with complex regional pain syndrome type 1. Mediators Inflamm. 2006;1:1–8
- . Platelet activating factor-induced ischemic bowel necrosis. The effect of platelet-activating factor acetylhydrolase. Pediatr Res. 1993;34:237–241
- Role of platelet-activating factor and tumor necrosis factor-alpha in neonatal necrotizing enterocolitis. J Pediatr. 1990;116:960–964
- Drotrecogin alfa (activated) prevents smoke-induced increases in pulmonary microvascular permeability and proinflammatory cytokine IL-1 beta in rats. Lung. 2004;182:319–330
- Activated protein C therapy in a rat heat stroke model. Crit Care Med. 2006;34:1960–1966
- Activated protein C preserves functional islet mass after intraportal transplantation: a novel link between endothelial cell activation, thrombosis, inflammation, and islet cell death. Diabetes. 2004;53:2804–2814
- Kinetics of immune parameters in a patient with sepsis caused by Streptococcus pyogenes treated with activated protein C. Scand J Infect Dis. 2004;36:485–488
- Activated protein C inhibits lipopolysaccharide-induced tumor necrosis factor-alpha production by inhibiting activation of both nuclear factor-kappa B and activator protein-1 in human monocytes. Thromb Haemost. 2002;88:267–273
- Gene expression profiling of inflamed human endothelial cells and influence of activated protein C. Circulation. 2004;110:2903–2909
- . Recombinant human activated protein C attenuates the inflammatory response in endothelium and monocytes by modulating nuclear factorkappaB. Crit Care Med. 2002;30:288–293
- . Biosynthesis and role of the endothelium-derived vasodilator, nitric oxide, in the gastric mucosa. Ann NY Acad Sci. 1992;664:126–129
- The role of nitric oxide in intestinal epithelial injury and restitution in neonatal necrotizing enterocolitis. Semin Perinatol. 2008;32:92–99
- . Nitric oxide synthase induction and intestinal epithelial cell viability in rats. Am J Physiol. 1993;265:214–218
- The role of inflammatory cytokines and nitric oxide in the pathogenesis of necrotizing enterocolitis. J Pediatr Surg. 1997;32:275–282
- Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3. Neuron. 2004;41:563–572
- Gene expression profile of antithrombotic protein c defines new mechanisms modulating inflammation and apoptosis. J Biol Chem. 2001;276:11199–11203
PII: S0022-3468(09)00590-9
doi: 10.1016/j.jpedsurg.2009.07.077
© 2010 Elsevier Inc. All rights reserved.
« Previous
Next »
Journal of Pediatric Surgery
Volume 45, Issue 3
, Pages 483-489
, March 2010
