Journal of Pediatric Surgery
Volume 45, Issue 8 , Pages 1591-1597 , August 2010

NOD2 mutations predict the risk for surgery in pediatric-onset Crohn's disease

  • Martin Lacher

      Affiliations

    • Department of Pediatric Surgery, Research Laboratories, University of Munich, D-80337 Munich, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +49 89 5160 7810/7811; fax: +49 89 5160 7815.
    • ,
  • Johanna Helmbrecht

      Affiliations

    • Department of Pediatric Surgery, Research Laboratories, University of Munich, D-80337 Munich, Germany
    • ,
  • Sebastian Schroepf

      Affiliations

    • Department of Pediatric Surgery, Research Laboratories, University of Munich, D-80337 Munich, Germany
    • ,
  • Sibylle Koletzko

      Affiliations

    • Department of Pediatrics, Division of Pediatric Gastroenterology, University of Munich, D-80337 Munich, Germany
    • ,
  • Antje Ballauff

      Affiliations

    • Department of Pediatrics, Division of Pediatric Gastroenterology, Universitätsklinikum Essen, University of Duisburg-Essen, D-45147 Essen, Germany
    • ,
  • Martin Classen

      Affiliations

    • Department of Pediatrics, Division of Pediatric Gastroenterology, Klinikum Links der Weser, D-28277 Bremen, Germany
    • ,
  • Holm Uhlig

      Affiliations

    • Department of Pediatrics, Division of Pediatric Gastroenterology, University of Leipzig, D-04103 Leipzig, Germany
    • ,
  • Jochen Hubertus

      Affiliations

    • Department of Pediatric Surgery, Research Laboratories, University of Munich, D-80337 Munich, Germany
    • ,
  • Dominik Hartl

      Affiliations

    • Department of Pediatric Surgery, Research Laboratories, University of Munich, D-80337 Munich, Germany
    • ,
  • Peter Lohse

      Affiliations

    • Department of Clinical Chemistry - Großhadern, University of Munich, D-81377 Munich, Germany
    • ,
  • Dietrich von Schweinitz

      Affiliations

    • Department of Pediatric Surgery, Research Laboratories, University of Munich, D-80337 Munich, Germany
    • ,
  • Roland Kappler

      Affiliations

    • Department of Pediatric Surgery, Research Laboratories, University of Munich, D-80337 Munich, Germany

Received 7 September 2009 ,Revised 9 October 2009 ,Accepted 10 October 2009.

References 

  1. Hugot JP, Chamaillard M, Zouali H, et al. Association of NOD2 leucine–rich repeat variants with susceptibility to Crohn's disease. Nature. 2001;411(6837):599–603
  2. Ogura Y, Bonen DK, Inohara N, et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature. 2001;411(6837):603–606
  3. Hampe J, Cuthbert A, Croucher PJ, et al. Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations. Lancet. 2001;357(9272):1925–1928
  4. Inohara N, Ogura Y, Fontalba A, et al. Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease. J Biol Chem. 2003;278(8):5509–5512
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  12. Tomer G, Ceballos C, Concepcion E, et al. NOD2/CARD15 variants are associated with lower weight at diagnosis in children with Crohn's disease. Am J Gastroenterol. 2003;98(11):2479–2484
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  21. Schnitzler F, Brand S, Staudinger T, et al. Eight novel CARD15 variants detected by DNA sequence analysis of the CARD15 gene in 111 patients with inflammatory bowel disease. Immunogenetics. 2006;58(2-3):99–106
  22. Newman B, Silverberg MS, Gu X, et al. CARD15 and HLA DRB1 alleles influence susceptibility and disease localization in Crohn's disease. Am J Gastroenterol. 2004;99(2):306–315
  23. Russell RK, Drummond HE, Nimmo EE, et al. Genotype-phenotype analysis in childhood-onset Crohn's disease: NOD2/CARD15 variants consistently predict phenotypic characteristics of severe disease. Inflamm Bowel Dis. 2005;11(11):955–964
  24. Kugathasan S, Loizides A, Babusukumar U, et al. Comparative phenotypic and CARD15 mutational analysis among African American, Hispanic, and White children with Crohn's disease. Inflamm Bowel Dis. 2005;11(7):631–638
  25. Vermeire S, Wild G, Kocher K, et al. CARD15 genetic variation in a Quebec population: prevalence, genotype-phenotype relationship, and haplotype structure. Am J Hum Genet. 2002;71(1):74–83
  26. Sutherland LR, Ramcharan S, Bryant H, et al. Effect of cigarette smoking on recurrence of Crohn's disease. Gastroenterology. 1990;98:1123–1128
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☆ Presented at the joint congress of the European Paediatric Surgeons' Association and the British Association of Paediatric Surgery, June 2009 in Graz/Austria.

☆☆ Authors have no conflicts of interest and no financial relationships relevant to this article to declare.

PII: S0022-3468(09)00829-X

doi: 10.1016/j.jpedsurg.2009.10.046

Journal of Pediatric Surgery
Volume 45, Issue 8 , Pages 1591-1597 , August 2010

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