Journal of Pediatric Surgery
Volume 45, Issue 8 , Pages 1627-1632 , August 2010

Sclerotherapy with bleomycin does not adversely affect facial nerve function in children with cervicofacial cystic lymphatic malformation

  • Afra Karavelioğlu

      Affiliations

    • Department of Pediatric Surgery, Hacettepe University Faculty of Medicine, Ankara 06100, Turkey
  • ,
  • Çağrı Mesut Temuçin

      Affiliations

    • Department of Neurology, Hacettepe University Faculty of Medicine, Ankara 06100, Turkey
  • ,
  • F. Cahit Tanyel

      Affiliations

    • Department of Pediatric Surgery, Hacettepe University Faculty of Medicine, Ankara 06100, Turkey
  • ,
  • Arbay O. Ciftci

      Affiliations

    • Department of Pediatric Surgery, Hacettepe University Faculty of Medicine, Ankara 06100, Turkey
  • ,
  • Mehmet Emin Şenocak

      Affiliations

    • Department of Pediatric Surgery, Hacettepe University Faculty of Medicine, Ankara 06100, Turkey
  • ,
  • İbrahim Karnak

      Affiliations

    • Department of Pediatric Surgery, Hacettepe University Faculty of Medicine, Ankara 06100, Turkey
    • Corresponding Author InformationCorresponding author. Department of Pediatric Surgery, Hacettepe University Faculty of Medicine, 06100 Ankara, Turkey. Tel.: +90 312 3115541; fax: +90 312 3115541.

Received 4 September 2009 ,Revised 16 December 2009 ,Accepted 16 December 2009.

References 

  1. Tansel T, Sayin OA, Ugurlucan M, et al. Successful bleomycin pleurodesis in a patient with prolonged pleural effusion after extracardiac fontan procedure. J Card Surg. 2006;21:585–586
  2. Hader WJ, Steinbok P, Hukin J, et al. Intratumoral therapy with bleomycin for cystic craniopharyngiomas in children. Pediatr Neurosurg. 2000;33:211–218
  3. Sanlialp I, Karnak I, Tanyel FC, et al. Sclerotherapy for lymphangioma in children. Int J Pediatr Otorhinolaryngol. 2003;67:795–800
  4. Mathur NN, Rana I, Bothra R, et al. Bleomycin sclerotherapy in congenital lymphatic and vascular malformations of the head and neck. Int J Pediatr Otorhinolaryngol. 2005;69:75–80
  5. Belen D, Er U, Yigitkanlı K, et al. Delayed neurotoxic complication of intracavitary bleomycin therapy for craniopharyngioma in a child who had previously undergone radiosurgery. J Neurosurg. 2007;106:391–393
  6. Savas A, Erdem A, Tun K, et al. Fatal toxic effect of bleomycin on brain tissue after intracystic chemotherapy for a craniopharyngioma: case report. Neurosurgery. 2000;46:213–217
  7. Takahashi H, Nakazawa S, Shimura T. Evaluation of postoperative intratumoral injection of bleomycin for craniopharyngioma in children. J Neurosurg. 1985;62:120–127
  8. Takahashi H, Yamaguchi F, Teramoto A. Long-term outcome and reconsideration of intracystic chemotherapy with bleomycin for craniopharyngioma in children. Childs Nerv Syst. 2005;21:701–704
  9. Okazaki T, Iwatani S, Yanai T, et al. Treatment of lymphangioma in children: our experience of 128 cases. J Pediatr Surg. 2007;42:386–389
  10. Ozen IO, Moralioglu S, Karabulut R, et al. Surgical treatment of cervicofacial cystic hygromas in children. ORL J Otorhinolaryngol Relat Spec. 2005;67:331–334
  11. Uba AF, Chirdan LB. Management of cystic lymphangioma in children: experience in Jos, Nigeria. Pediatr Surg Int. 2006;22:353–356
  12. Som PM, Lidov M, Lawson W. Hemorrhaged cystic hygroma and facial nerve paralysis: CT and MR findings. J Comput Assist Tomogr. 1990;14:668–671
  13. Mozolewski E, Zapolna-Kazmierczak W, Kosciesza B. Problems of lymphangioma of the parotid gland and adjacent tissues. Otolaryngol Pol. 1989;42:407–413
  14. Som PM, Zimmermann RA, Biller HF. Cystic hygroma and facial nerve paralysis: a rare association. J Comput Assist Tomogr. 1984;8:110–113
  15. Winterer JT, Laubenberger J, Berger W, et al. Radiological findings in lymphangioma of the posterior tibial nerve. J Comput Assist Tomogr. 1998;22:28–30
  16. Sung MW, Lee DW, Kim DY, et al. Sclerotherapy with picibanil (OK-432) for congenital lymphatic malformation in the head and neck. Laryngoscope. 2001;111:1430–1433
  17. Lin PJ, Guo YC, Lin JY, et al. Facial nerve conduction after sclerotherapy in children with facial lymphatic malformations: reports of two cases. Tohoku J Exp Med. 2007;211:401–406
  18. Levin VA, Byrd D, Sikic BI, et al. Central nervous system toxicity and cerebrospinal fluid pharmacokinetics of intraventricularly administered bleomycin in beagles. Cancer Res. 1985;45:3810–3815
  19. Sawada H, Ibi M, Kihara T, et al. Neuroprotective mechanism of glial cell line-derived neurotrophic factor in mesencephalic neurons. J Neurochem. 2000;74:1175–1184
  20. Nakazawa S, Ohwaki K, Shimura T, et al. A new treatment of malignant brain tumor. I. Local injection of bleomycin. No Shinkei Geka. 1981;9:1487–1493
  21. Dumitru D, Amato AA, Zwarts M. Electrodiagnostic Medicine. Philadelphia: Hanley & Belfus; 2001;

PII: S0022-3468(09)01070-7

doi: 10.1016/j.jpedsurg.2009.12.014

Journal of Pediatric Surgery
Volume 45, Issue 8 , Pages 1627-1632 , August 2010