Journal of Pediatric Surgery
Volume 45, Issue 8 , Pages 1581-1590 , August 2010

Morphological and functional changes in the colon after massive small bowel resection

  • Kate L. Healey

      Affiliations

    • Murdoch Children's Research Institute, Parkville, Victoria, Australia
    • ,
  • Julie E. Bines

      Affiliations

    • Murdoch Children's Research Institute, Parkville, Victoria, Australia
    • Department of Gastroenterology and Clinical Nutrition, Royal Children's Hospital, Victoria, Australia
    • Department of Pediatrics, The University of Melbourne, Parkville, Victoria, Australia
    • ,
  • Sarah L. Thomas

      Affiliations

    • Murdoch Children's Research Institute, Parkville, Victoria, Australia
    • ,
  • Guineva Wilson

      Affiliations

    • Department of Surgery, Royal Children's Hospital, Victoria, Australia
    • ,
  • Russell G. Taylor

      Affiliations

    • Department of Surgery, Royal Children's Hospital, Victoria, Australia
    • ,
  • Magdy Sourial

      Affiliations

    • Department of Surgery, Royal Children's Hospital, Victoria, Australia
    • ,
  • Prue M. Pereira-Fantini

      Affiliations

    • Murdoch Children's Research Institute, Parkville, Victoria, Australia
    • Corresponding Author InformationCorresponding author. Intestinal Failure and Clinical Nutrition Group, Murdoch Children's Research Institute, Parkville 3052, Australia. Tel.: +61 3 8341 6452; fax: +61 3 8341 6449.
    • Dr Prue Pereira-Fantini is supported by a grant provided by the Murdoch Children's Research Institute.

Received 3 November 2009 ,Revised 3 February 2010 ,Accepted 3 February 2010.

References 

  1. Sukhotnik I, Siplovich L, Shiloni E, et al. Intestinal adaptation in short bowel syndrome in infants and children: a collective review. Pediatr Surg Int. 2002;18(4):258–263
  2. Pereira PM, Bines JE. New growth factor therapies aimed at improving intestinal adaptation in short bowel syndrome. J Gastroenterol Hepatol. 2006;21(6):932–940
  3. Taylor RG, Fuller PJ. Humoral regulation of intestinal adaptation. Baillieres Clin Endocrinol Metab. 1994;8(1):165–183
  4. Bines JE, Taylor RG, Justice F, et al. Influence of diet complexity on intestinal adaptation following massive small bowel resection in a preclinical model. J Gastroenterol Hepatol. 2002;17(11):1170–1179
  5. Bines J, Francis D, Hill D. Reducing parenteral requirement in children with short bowel syndrome: impact of an amino acid-based complete infant formula. J Pediatr Gastroenterol Nutr. 1998;26(2):123–128
  6. Pereira-Fantini PM, Thomas SL, Taylor RG, et al. Colostrum supplementation restores insulin-like growth factor-1 levels and alters muscle morphology following massive small bowel resection. JPEN J Parenter Enteral Nutr. 2008;32(3):266–275
  7. Pereira-Fantini PM, Nagy ES, Thomas SL, et al. GLP-2 administration results in increased proliferation but paradoxically an adverse outcome in a juvenile piglet model of short bowel syndrome. J Pediatr Gastroenterol Nutr. 2008;46(1):20–28
  8. Moughan PJ, Birtles MJ, Cranwell PD, et al. The piglet as a model animal for studying aspects of digestion and absorption in milk-fed human infants. World Rev Nutr Diet. 1992;67:40–113
  9. Miller ER, Ullrey DE. The pig as a model for human nutrition. Annu Rev Nutr. 1987;7:361–382
  10. Nagy ES, Paris MC, Taylor RG, et al. Colostrum protein concentrate enhances intestinal adaptation after massive small bowel resection in juvenile pigs. J Pediatr Gastroenterol Nutr. 2004;39(5):487–492
  11. Paris MC, Fuller PJ, Carstensen B, et al. Plasma GLP-2 levels and intestinal markers in the juvenile pig during intestinal adaptation: effects of different diet regimens. Dig Dis Sci. 2004;49(10):1688–1695
  12. Nutrient requirements of swine. In: 10th Ed. Subcommittee on Swine Nutrition Committee on Animal Nutrition Board on Agriculture National Research Council. Washington D.C. US: The National Academies Press; 2008;p. 111
  13. Simon TC, Roth KA, Gordon JI. Use of transgenic mice to map cis-acting elements in the liver fatty acid-binding protein gene (Fabpl) that regulate its cell lineage-specific, differentiation-dependent, and spatial patterns of expression in the gut epithelium and in the liver acinus. J Biol Chem. 1993;268(24):18345–18358
  14. Hermiston ML, Green RP, Gordon JI. Chimeric-transgenic mice represent a powerful tool for studying how the proliferation and differentiation programs of intestinal epithelial cell lineages are regulated. Proc Natl Acad Sci U S A. 1993;90(19):8866–8870
  15. Hagan MM. Peptide YY: a key mediator of orexigenic behavior. Peptides. 2002;23(2):377–382
  16. Mannon PJ. Peptide YY as a growth factor for intestinal epithelium. Peptides. 2002;23(2):383–388
  17. Buchman AL. The clinical management of short bowel syndrome: steps to avoid parenteral nutrition. Nutrition. 1997;13(10):907–913
  18. Weale AR, Edwards AG, Bailey M, et al. Intestinal adaptation after massive intestinal resection. Postgrad Med J. 2005;81(953):178–184
  19. Joly F, Mayeur C, Messing B, et al. Morphological adaptation with preserved proliferation/transporter content in the colon of patients with short bowel syndrome. Am J Physiol Gastrointest Liver Physiol. 2009;297(1):G116–123
  20. Dekaney CM, von Allmen DC, Garrison AP, et al. Bacterial-dependent up-regulation of intestinal bile acid binding protein and transport is FXR-mediated following ileocecal resection. Surgery. 2008;144(2):174–181
  21. Jeppesen PB. Growth factors in short bowel syndrome patients. Gastroenterol Clin North Am 2007;36(1):109-21, vii.
  22. Castell T, Gomez de Segura IA, Vazquez I, et al. Somatostatin blockade improves the proliferative response but not intestinal morphological growth after small bowel resection in rats. Eur J Surg. 2001;167(1):54–59
  23. Baksheev L, Fuller PJ. Gene expression in the adapting small bowel after massive small bowel resection. J Gastroenterol. 2006;41(11):1041–1052
  24. Baksheev L, Fuller PJ. Humoral factors in intestinal adaptation. Trends Endocrinol Metab. 2000;11(10):401–405
  25. Zhang W, Li N, Zhu W, et al. Peptide YY induces enterocyte proliferation in a rat model with total enteral nutrition after distal bowel resection. Pediatr Surg Int. 2008;24(8):913–919
  26. Zhu W, Zhang W, Gong J, et al. Peptide YY induces intestinal proliferation in peptide YY knockout mice with total enteral nutrition after massive small bowel resection. J Pediatr Gastroenterol Nutr. 2009;48(5):517–525
  27. Jarboe MD, Juno RJ, Stehr W, et al. Epidermal growth factor receptor signaling regulates goblet cell production after small bowel resection. J Pediatr Surg. 2005;40(1):92–97
  28. Kjellev S, Nexo E, Thim L, et al. Systemically administered trefoil factors are secreted into the gastric lumen and increase the viscosity of gastric contents. Br J Pharmacol. 2006;149(1):92–99
  29. Taupin DR, Kinoshita K, Podolsky DK. Intestinal trefoil factor confers colonic epithelial resistance to apoptosis. Proc Natl Acad Sci U S A. 2000;97(2):799–804
  30. Thim L, Mortz E. Isolation and characterization of putative trefoil peptide receptors. Regul Pept. 2000;90(1-3):61–68
  31. Erwin CR, Jarboe MD, Sartor MA, et al. Developmental characteristics of adapting mouse small intestine crypt cells. Gastroenterology. 2006;130(4):1324–1332
  32. Rubin DC, Swietlicki EA, Iordanov H, et al. Novel goblet cell gene related to IgGFcgammaBP is regulated in adapting gut after small bowel resection. Am J Physiol Gastrointest Liver Physiol. 2000;279(5):G1003–1010
  33. Lentze MJ. Intestinal adaptation in short bowel syndrome. Eur J Pediatr. 1989;148(4):294–299
  34. Vanderhoof JA, Young RJ. Enteral and parenteral nutrition in the care of patients with short-bowel syndrome. Best Pract Res Clin Gastroenterol. 2003;17(6):997–1015
  35. Vanderhoof JA, Langnas AN, Pinch LW, et al. Short bowel syndrome. J Pediatr Gastroenterol Nutr. 1992;14(4):359–370
  36. Sukhotnik I, Mor-Vaknin N, Drongowski RA, et al. Effect of dietary fat on fat absorption and concomitant plasma and tissue fat composition in a rat model of short bowel syndrome. Pediatr Surg Int. 2004;20(3):185–191

☆ There are no conflicts of interest to disclose for any of the authors.

PII: S0022-3468(10)00159-4

doi: 10.1016/j.jpedsurg.2010.02.040

Journal of Pediatric Surgery
Volume 45, Issue 8 , Pages 1581-1590 , August 2010

Article Tools

* Image Usage & Resolution