Journal of Pediatric Surgery
Volume 31, Issue 1 , Pages 96-99 , January 1996

Lack of intestinal pacemaker (C-KIT-positive) cells in infantile hypertrophic pyloric stenosis

  • Atsuyuki Yamataka

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Atsuyuki Yamataka, MD, Department of Pediatric Surgery, Juntendo University School of Medicine, 2-1-1, Hongo, Bunkyo, Tokyo 113, Japan.
    • Division of Pediatric Surgery, Department of Surgery, Dokkyo University School of Medicine, Tochigi, Japan
    • the Department of Pediatric Surgery, Juntendo University School of Medicine, Tokyo, Japan.
    • ,
  • Toshio Fujiwara

      Affiliations

    • Division of Pediatric Surgery, Department of Surgery, Dokkyo University School of Medicine, Tochigi, Japan
    • the Department of Pediatric Surgery, Juntendo University School of Medicine, Tokyo, Japan.
    • ,
  • Yoshifumi Kato

      Affiliations

    • Division of Pediatric Surgery, Department of Surgery, Dokkyo University School of Medicine, Tochigi, Japan
    • the Department of Pediatric Surgery, Juntendo University School of Medicine, Tokyo, Japan.
    • ,
  • Tadaharu Okazaki

      Affiliations

    • Division of Pediatric Surgery, Department of Surgery, Dokkyo University School of Medicine, Tochigi, Japan
    • the Department of Pediatric Surgery, Juntendo University School of Medicine, Tokyo, Japan.
    • ,
  • Masakatsu Suhagawa

      Affiliations

    • Division of Pediatric Surgery, Department of Surgery, Dokkyo University School of Medicine, Tochigi, Japan
    • the Department of Pediatric Surgery, Juntendo University School of Medicine, Tokyo, Japan.
    • ,
  • Takeshi Miyano

      Affiliations

    • Division of Pediatric Surgery, Department of Surgery, Dokkyo University School of Medicine, Tochigi, Japan
    • the Department of Pediatric Surgery, Juntendo University School of Medicine, Tokyo, Japan.

References 

  1. Benson CD. Infantile hypertrophic pyloric stenosis. In:  Welch KJ,  Randolph JF,  Ravitch MM, et al. editor. Pediatric Surgery. ed 4. Chicago, IL: Year Book Medical; 1986;p. 811–816 chap 81
  2. Habbick BF, Khanna C, To T. Infantile hypertrophic pyloric stenosis: A study of feeding practices and other possible causes. Can Med Assoc J. 1989;140:401–404
  3. Wattchow DA, Cass DT, Furness JB, et al.  Abnormalities of peptide-containing nerve fibers in infantile hypertrophic pyloric stenosis. Gastroenterology. 1987;92:443–448
  4. Vanderwinden JM, De Laet MH, Schiffmann SN, et al.  Nitric oxide synthase distribution in the enteric nervous system of Hirschsprung's disease. Gastroenterology. 1993;105:969–973
  5. Dieler R, Schroder JM. Myenteric plexus neuropathy in infantile hypertrophic pyloric stenosis. Acta Neuropathol. 1989;78:649–661
  6. Yarden Y, Kuang W-J, Yang-Feng T, et al.  Human proto-oncogene c-kit: A new cell surface receptor tyrosine kinase for an unidentified ligand. EMBO J. 1987;6:3341–3351
  7. Zsebo KM, Williams DA, Geissler EN, et al.  Stem cell factor is encoded at the SI locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor. Cell. 1990;63:213–224
  8. Maeda H, Yamagata A, Nishikawa S, et al.  Requirement of c-kit for development of intestinal pacemaker system. Development. 1992;116:369–375
  9. Sato D, Tokutomi N, Nishi K. Developmental failure of intestinal Ca2+ mobilization in anti-c-kit monoclonal antibodytreated mice. Jpn J Pharmacol. 1994;64(suppl 1):159
  10. Huizinga JD, Thuneberg L, Kluppel M, et al.  W/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activity. Nature. 1995;373:347–349
  11. Yamataka A, Kato Y, Tibboel D, et al.  A lack of intestinal pacemaker (c-kit) in aganglionic bowel of patients with Hirschsprung's disease. J Pediatr Surg. 1995;30:441–444
  12. Qui FH, Ray P, Brown K, et al.  Primary structure of c-kit: Relationship with the receptor kinase family-Oncogene activation of v-kit involves deletion of extracellular domain and C-terminus. EMBO J. 1988;7:1003–1011
  13. Thuneberg L. Interstitial cell of Cajal: Intestinal pacemaker cells?. Adv Anat Embryol Cell Biol. 1982;71:1–93
  14. Langer JC, Berezin I, Daniel EE: Hypertrophic pyloric stenosis: Ultrastructural abnormalities of enteric nerves and the interstitial cells of Cajal. J Pediatr Surg (in press)
  15. Allescher H-D, Daniel EE, Dent J, et al.  Extrinsic and intrinsic neural control of pyloric sphincter pressure in the dog. J Physiol (Lond). 1988;401:17–38
  16. Daniel EE, Berezin I, Allescher HD, et al.  Morphology of the canine pyloric sphincter in relation to function. Can J Physiol Pharmacol. 1989;67:1560–1573
  17. Orr-Urtreger A, Avivi A, Zimmer Y, et al.  Developmental expression of c-kit, a proto-oncogene encoded by the W locus. Development. 1990;109:911–923
  18. Hayes MA, Goldenberg IS. The problems of infantile pyloric stenosis. Int Abstr Surg. 1957;104:105–138
  19. Wesley JR, DiPietro MA, Coran AG. Pyloric stenosis: Evolution from pylorospasm?. Pediatr Surg Int. 1990;5:425–428
  20. Morii E, Hirata T, Hirota S, et al.  Types of neurons that express mRNA of c-kit and its ligand in developing murine cerebellum. Acta Histochem Cytochem. 1993;26:359–364
  21. Okazaki T, Yamataka A, Fujiwara T, et al.  Abnormal distribution of nerve terminals in infantile hypertrophic pyloric stenosis. J Pediatr Surg. 1994;29:655–658

☆ Presented at the 26th Annual Meeting of the American Pediatric Surgical Association, Boca Raton, Florida, May 20–23, 1995.

PII: S0022-3468(96)90327-9

Journal of Pediatric Surgery
Volume 31, Issue 1 , Pages 96-99 , January 1996

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