Journal of Pediatric Surgery
Volume 31, Issue 4 , Pages 486-489 , April 1996

The microenvironment influences the pattern of bacterial translocation in formula-fed neonates

  • Henri R. Ford

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Henri R. Ford, MD, Department of Pediatric Surgery, Children's Hospital of Pittsburgh, 3705 Fifth Ave, Pittsburgh, PA 15213-2583.
    • Department of Surgery, University of Pittsburgh School of Medicine Pittsburgh, PA, USA
    • the Department of Pediatric Surgery, Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.
    • ,
  • Ali Avanogˇlu

      Affiliations

    • Department of Surgery, University of Pittsburgh School of Medicine Pittsburgh, PA, USA
    • the Department of Pediatric Surgery, Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.
    • ,
  • Paulo R. Boechat

      Affiliations

    • Department of Surgery, University of Pittsburgh School of Medicine Pittsburgh, PA, USA
    • the Department of Pediatric Surgery, Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.
    • ,
  • David Melgoza

      Affiliations

    • Department of Surgery, University of Pittsburgh School of Medicine Pittsburgh, PA, USA
    • the Department of Pediatric Surgery, Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.
    • ,
  • Ronnie S. LumCheong

      Affiliations

    • Department of Surgery, University of Pittsburgh School of Medicine Pittsburgh, PA, USA
    • the Department of Pediatric Surgery, Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.
    • ,
  • Patricia Boyle

      Affiliations

    • Department of Surgery, University of Pittsburgh School of Medicine Pittsburgh, PA, USA
    • the Department of Pediatric Surgery, Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.
    • ,
  • Melissa Garrett

      Affiliations

    • Department of Surgery, University of Pittsburgh School of Medicine Pittsburgh, PA, USA
    • the Department of Pediatric Surgery, Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.
    • ,
  • Marc I. Rowe

      Affiliations

    • Department of Surgery, University of Pittsburgh School of Medicine Pittsburgh, PA, USA
    • the Department of Pediatric Surgery, Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.

Reference 

  1. Alexander JW, Boyce ST, Babcock GF, et al. The process of microbial translocation. Ann Surg. 1990;212:496–512
  2. Deitch EA, Berg RD. Bacterial translocation from the gut: A mechanism of infection. J Burn Care Rehabil. 1987;8:475–582
  3. Deitch EA, Berg R, Specian R. Endotoxin promotes the translocation of bacteria from the gut. Arch Surg. 1987;122:185–190
  4. Deitch EA, Morrison J, Berg RD, et al. Effect of hemorrhagic shock on bacterial translocation, intestinal morphology, and intestinal permeability in conventional and antibody-decontaminated rats. Crit Care Med. 1990;18:528–536
  5. Deitch EA, Kemper AC, Specian RD, et al. A study of the relationships among survival, gut-origin sepsis, and bacterial translocation in a model of systemic inflammation. J Trauma. 1992;32:141–147
  6. Go LL, Albanese CT, Watkins SC, et al. Breast milk protects the neonate from bacterial translocation. J Pediatr Surg. 1994;29:1059–1064
  7. Go LL, Ford HR, Watkins SC, et al. Quantitative and morphologic analysis of bacterial translocation in neonates. Arch Surg. 1994;129:1184–1190
  8. Butler JE. Immunologic aspects of breast-feeding, anti-infectious activity of breast milk. Semin Perinatol. 1979;3:255–270
  9. Goldman AS, Garza C, Nicholas BL, et al. Immunologic factors in human milk during the first year of lactation. J Pediatr. 1982;100:563–567
  10. Slade HB, Schwartz SA. Mucosal immunity: The immunology of breast milk. J Allergy Clin Immunol. 1987;80:348–358
  11. Abraham R, Ogra PL. Mucosal microenvironment and mucosal response. Am J Trop Med Hyg. 1994;50:3–9
  12. Ayliffe GA. Role of the environment of the operating suite in surgical wound-infection. Rev Infect Dis. 1991;13:S800–S804
  13. Smith H. The influence of the host on microbes that cause disease. In: ed 4. Proc R Soc Lond. 246:1991;p. 97–105
  14. Cutting WA. Breast-feeding and HIV—A balance of risk. J Trop Pediatr. 1994;40:6–11

 Presented at the 42nd Annual International Congress of the British Association of Paediatric Surgeons, Sheffield, England, July 25–28, 1995.

 Supported in part by a grant from the H.J. Heinz Foundation.

PII: S0022-3468(96)90480-7

Journal of Pediatric Surgery
Volume 31, Issue 4 , Pages 486-489 , April 1996

Article Tools