Journal of Pediatric Surgery
Volume 32, Issue 1 , Pages 41-43, January 1997

Hyaluronic acid of wound fluid in adult and fetal rabbits☆

  • Toshio Sawai

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Toshio Sawai, MD, Department of Pediatric Surgery, Osaka University Medical School, 2-2 Yamada-oka, Suita, Osaka 565, Japan.
    • Department of Pediatric Surgery, Osaka University, Medical School, Osaka, Japan.
    • Department of Biochemistry, Osaka University, Medical School, Osaka, Japan.
    • the Institute for Molecular Science of Medicine, Aichi Medical University, Aichi, Japan.
    • ,
  • Noriaki Usui

      Affiliations

    • Department of Pediatric Surgery, Osaka University, Medical School, Osaka, Japan.
    • Department of Biochemistry, Osaka University, Medical School, Osaka, Japan.
    • the Institute for Molecular Science of Medicine, Aichi Medical University, Aichi, Japan.
    • ,
  • Kinya Sando

      Affiliations

    • Department of Pediatric Surgery, Osaka University, Medical School, Osaka, Japan.
    • Department of Biochemistry, Osaka University, Medical School, Osaka, Japan.
    • the Institute for Molecular Science of Medicine, Aichi Medical University, Aichi, Japan.
    • ,
  • Yuichi Fukui

      Affiliations

    • Department of Pediatric Surgery, Osaka University, Medical School, Osaka, Japan.
    • Department of Biochemistry, Osaka University, Medical School, Osaka, Japan.
    • the Institute for Molecular Science of Medicine, Aichi Medical University, Aichi, Japan.
    • ,
  • Shinkichi Kamata

      Affiliations

    • Department of Pediatric Surgery, Osaka University, Medical School, Osaka, Japan.
    • Department of Biochemistry, Osaka University, Medical School, Osaka, Japan.
    • the Institute for Molecular Science of Medicine, Aichi Medical University, Aichi, Japan.
    • ,
  • Akira Okada

      Affiliations

    • Department of Pediatric Surgery, Osaka University, Medical School, Osaka, Japan.
    • Department of Biochemistry, Osaka University, Medical School, Osaka, Japan.
    • the Institute for Molecular Science of Medicine, Aichi Medical University, Aichi, Japan.
    • ,
  • Naoyuki Taniguchi

      Affiliations

    • Department of Pediatric Surgery, Osaka University, Medical School, Osaka, Japan.
    • Department of Biochemistry, Osaka University, Medical School, Osaka, Japan.
    • the Institute for Molecular Science of Medicine, Aichi Medical University, Aichi, Japan.
    • ,
  • Naoki Itano

      Affiliations

    • Department of Pediatric Surgery, Osaka University, Medical School, Osaka, Japan.
    • Department of Biochemistry, Osaka University, Medical School, Osaka, Japan.
    • the Institute for Molecular Science of Medicine, Aichi Medical University, Aichi, Japan.
    • ,
  • Koji Kimata

      Affiliations

    • Department of Pediatric Surgery, Osaka University, Medical School, Osaka, Japan.
    • Department of Biochemistry, Osaka University, Medical School, Osaka, Japan.
    • the Institute for Molecular Science of Medicine, Aichi Medical University, Aichi, Japan.

Abstract 

Fetal wound healing proceeds without fibrosis or scar formation in contrast to adult wound healing. The mechanisms responsible for this remarkable process are mediated in part through a fetal wound extracellular matrix rich in hyaluronic acid (HA). Polyvinylalcohol sponge (PVA) wound implants were placed pervertebrally at 24 days' gestation in fetal (N = 118) rabbits and in adult (N = 44) rabbits, and then harvested at 1, 2, 3, 4, 5, and 7 days postwounding. To analyze the fetal and adult wound matrix, the HA concentration of wound fluid within the PVA sponge was quantitated using a newly developed assay. A significantly increased (P<.05) HA deposition on days 1 through 7 in the fetal wounds was found compared with the adult wound. These observations may suggest an important physiologic role in fetal wound healing by providing a more fluid and malleable matrix. These results, coupled with earlier findings of the lack of an acute inflammatory response in the fetus, further support the hypothesis that fetal response to injury is significantly different from adult response in this prescience of an implanted PVA sponge.

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☆ Presented at the 29th Annual Meeting of the Pacific Association of Pediatric Surgeons, Singapore, May 12–15, 1996.

PII: S0022-3468(97)90089-0

Journal of Pediatric Surgery
Volume 32, Issue 1 , Pages 41-43, January 1997

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