Journal of Pediatric Surgery
Volume 32, Issue 11 , Pages 1620-1623, November 1997

Histopathologic findings of advanced neuroblastoma after intensive induction chemotherapy☆☆☆

  • J Miyauchi

      Affiliations

    • Department of Pathology, National Children's Hospital, Tokyo, Japan
    • Department of Surgery, National Children's Hospital, Tokyo, Japan
    • the Department of Pathology, University of Tokyo, Tokyo, Japan
    • the Department of Pediatric Surgery, University of Tokyo, Tokyo, Japan
    • the Department Pediatrics, University of Tokyo, Tokyo, Japan
    • the 2nd Department of Surgery, Nagoya City University, Nagoya, Japan
    • the Department of Hematology/Oncology, Polish-American Children's Hospital, Krakow, Poland.
    • ,
  • K Matsuoka

      Affiliations

    • Department of Pathology, National Children's Hospital, Tokyo, Japan
    • Department of Surgery, National Children's Hospital, Tokyo, Japan
    • the Department of Pathology, University of Tokyo, Tokyo, Japan
    • the Department of Pediatric Surgery, University of Tokyo, Tokyo, Japan
    • the Department Pediatrics, University of Tokyo, Tokyo, Japan
    • the 2nd Department of Surgery, Nagoya City University, Nagoya, Japan
    • the Department of Hematology/Oncology, Polish-American Children's Hospital, Krakow, Poland.
    • ,
  • T Oka

      Affiliations

    • Department of Pathology, National Children's Hospital, Tokyo, Japan
    • Department of Surgery, National Children's Hospital, Tokyo, Japan
    • the Department of Pathology, University of Tokyo, Tokyo, Japan
    • the Department of Pediatric Surgery, University of Tokyo, Tokyo, Japan
    • the Department Pediatrics, University of Tokyo, Tokyo, Japan
    • the 2nd Department of Surgery, Nagoya City University, Nagoya, Japan
    • the Department of Hematology/Oncology, Polish-American Children's Hospital, Krakow, Poland.
    • ,
  • Y Kamii

      Affiliations

    • Department of Pathology, National Children's Hospital, Tokyo, Japan
    • Department of Surgery, National Children's Hospital, Tokyo, Japan
    • the Department of Pathology, University of Tokyo, Tokyo, Japan
    • the Department of Pediatric Surgery, University of Tokyo, Tokyo, Japan
    • the Department Pediatrics, University of Tokyo, Tokyo, Japan
    • the 2nd Department of Surgery, Nagoya City University, Nagoya, Japan
    • the Department of Hematology/Oncology, Polish-American Children's Hospital, Krakow, Poland.
    • ,
  • T Honna

      Affiliations

    • Department of Pathology, National Children's Hospital, Tokyo, Japan
    • Department of Surgery, National Children's Hospital, Tokyo, Japan
    • the Department of Pathology, University of Tokyo, Tokyo, Japan
    • the Department of Pediatric Surgery, University of Tokyo, Tokyo, Japan
    • the Department Pediatrics, University of Tokyo, Tokyo, Japan
    • the 2nd Department of Surgery, Nagoya City University, Nagoya, Japan
    • the Department of Hematology/Oncology, Polish-American Children's Hospital, Krakow, Poland.
    • ,
  • F Bessho

      Affiliations

    • Department of Pathology, National Children's Hospital, Tokyo, Japan
    • Department of Surgery, National Children's Hospital, Tokyo, Japan
    • the Department of Pathology, University of Tokyo, Tokyo, Japan
    • the Department of Pediatric Surgery, University of Tokyo, Tokyo, Japan
    • the Department Pediatrics, University of Tokyo, Tokyo, Japan
    • the 2nd Department of Surgery, Nagoya City University, Nagoya, Japan
    • the Department of Hematology/Oncology, Polish-American Children's Hospital, Krakow, Poland.
    • ,
  • S Sasaki

      Affiliations

    • Department of Pathology, National Children's Hospital, Tokyo, Japan
    • Department of Surgery, National Children's Hospital, Tokyo, Japan
    • the Department of Pathology, University of Tokyo, Tokyo, Japan
    • the Department of Pediatric Surgery, University of Tokyo, Tokyo, Japan
    • the Department Pediatrics, University of Tokyo, Tokyo, Japan
    • the 2nd Department of Surgery, Nagoya City University, Nagoya, Japan
    • the Department of Hematology/Oncology, Polish-American Children's Hospital, Krakow, Poland.
    • ,
  • J Melanowska

      Affiliations

    • Department of Pathology, National Children's Hospital, Tokyo, Japan
    • Department of Surgery, National Children's Hospital, Tokyo, Japan
    • the Department of Pathology, University of Tokyo, Tokyo, Japan
    • the Department of Pediatric Surgery, University of Tokyo, Tokyo, Japan
    • the Department Pediatrics, University of Tokyo, Tokyo, Japan
    • the 2nd Department of Surgery, Nagoya City University, Nagoya, Japan
    • the Department of Hematology/Oncology, Polish-American Children's Hospital, Krakow, Poland.
    • ,
  • Y Tsuchida

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Y. Tsuchida, MD, Director, Gunma Children's Medical Center, 779 Shimohakoda, Hokkitsu, Seta-gun, Gunma 377, Japan.
    • Department of Pathology, National Children's Hospital, Tokyo, Japan
    • Department of Surgery, National Children's Hospital, Tokyo, Japan
    • the Department of Pathology, University of Tokyo, Tokyo, Japan
    • the Department of Pediatric Surgery, University of Tokyo, Tokyo, Japan
    • the Department Pediatrics, University of Tokyo, Tokyo, Japan
    • the 2nd Department of Surgery, Nagoya City University, Nagoya, Japan
    • the Department of Hematology/Oncology, Polish-American Children's Hospital, Krakow, Poland.

Abstract 

Background: Histopathologic findings of advanced neuroblastoma after intensive induction chemotherapy have not been studied well.

Methods: In the present study, all of the surgical specimens from 19 patients who had advanced abdominal neuroblastoma and were pretreated intensively with the protocol of the Study Group of Japan were reviewed. The authors found that dissection of the contralateral lymph nodes is mandatory in advanced neuroblastoma when the goal is the complete dissection of the abdominal disease. Effects of chemotherapy were graded histologically according to the ratio of viable residual neuroblastoma tissue to total areas of the tumor, including neuroblastoma, ganglioneuroblastoma, ganglioneuroma, hemorrhage, necrosis and fibrosis, in five ranks from (+++) to (−).

Conclusions: The newly introduced, highly cytotoxic regimen of the Japanese protocol, designated “A3”, appears to be more effective histologically than the conventional regimen, designated “A1” or “new A1.” Effects designated (+++) or (++) were prerequisites for survival in stage IV disease, but some stage III patients with the (+) effect survived.

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☆ Presented at the 30th Annual Meeting of the Pacific Association of Pediatric Surgeons, Phoenix, Arizona, May 9–13, 1997.

☆☆ This work was supported by Grants-in-Aid for Cancer Research (7–31 and 9–14) from the Ministry of Health and Welfare of the Government of Japan.

PII: S0022-3468(97)90467-X

Journal of Pediatric Surgery
Volume 32, Issue 11 , Pages 1620-1623, November 1997

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