Journal of Pediatric Surgery
Volume 32, Issue 11 , Pages 1620-1623 , November 1997

Histopathologic findings of advanced neuroblastoma after intensive induction chemotherapy

  • J Miyauchi

      Affiliations

    • Department of Pathology, National Children's Hospital, Tokyo, Japan
    • Department of Surgery, National Children's Hospital, Tokyo, Japan
    • the Department of Pathology, University of Tokyo, Tokyo, Japan
    • the Department of Pediatric Surgery, University of Tokyo, Tokyo, Japan
    • the Department Pediatrics, University of Tokyo, Tokyo, Japan
    • the 2nd Department of Surgery, Nagoya City University, Nagoya, Japan
    • the Department of Hematology/Oncology, Polish-American Children's Hospital, Krakow, Poland.
    • ,
  • K Matsuoka

      Affiliations

    • Department of Pathology, National Children's Hospital, Tokyo, Japan
    • Department of Surgery, National Children's Hospital, Tokyo, Japan
    • the Department of Pathology, University of Tokyo, Tokyo, Japan
    • the Department of Pediatric Surgery, University of Tokyo, Tokyo, Japan
    • the Department Pediatrics, University of Tokyo, Tokyo, Japan
    • the 2nd Department of Surgery, Nagoya City University, Nagoya, Japan
    • the Department of Hematology/Oncology, Polish-American Children's Hospital, Krakow, Poland.
    • ,
  • T Oka

      Affiliations

    • Department of Pathology, National Children's Hospital, Tokyo, Japan
    • Department of Surgery, National Children's Hospital, Tokyo, Japan
    • the Department of Pathology, University of Tokyo, Tokyo, Japan
    • the Department of Pediatric Surgery, University of Tokyo, Tokyo, Japan
    • the Department Pediatrics, University of Tokyo, Tokyo, Japan
    • the 2nd Department of Surgery, Nagoya City University, Nagoya, Japan
    • the Department of Hematology/Oncology, Polish-American Children's Hospital, Krakow, Poland.
    • ,
  • Y Kamii

      Affiliations

    • Department of Pathology, National Children's Hospital, Tokyo, Japan
    • Department of Surgery, National Children's Hospital, Tokyo, Japan
    • the Department of Pathology, University of Tokyo, Tokyo, Japan
    • the Department of Pediatric Surgery, University of Tokyo, Tokyo, Japan
    • the Department Pediatrics, University of Tokyo, Tokyo, Japan
    • the 2nd Department of Surgery, Nagoya City University, Nagoya, Japan
    • the Department of Hematology/Oncology, Polish-American Children's Hospital, Krakow, Poland.
    • ,
  • T Honna

      Affiliations

    • Department of Pathology, National Children's Hospital, Tokyo, Japan
    • Department of Surgery, National Children's Hospital, Tokyo, Japan
    • the Department of Pathology, University of Tokyo, Tokyo, Japan
    • the Department of Pediatric Surgery, University of Tokyo, Tokyo, Japan
    • the Department Pediatrics, University of Tokyo, Tokyo, Japan
    • the 2nd Department of Surgery, Nagoya City University, Nagoya, Japan
    • the Department of Hematology/Oncology, Polish-American Children's Hospital, Krakow, Poland.
    • ,
  • F Bessho

      Affiliations

    • Department of Pathology, National Children's Hospital, Tokyo, Japan
    • Department of Surgery, National Children's Hospital, Tokyo, Japan
    • the Department of Pathology, University of Tokyo, Tokyo, Japan
    • the Department of Pediatric Surgery, University of Tokyo, Tokyo, Japan
    • the Department Pediatrics, University of Tokyo, Tokyo, Japan
    • the 2nd Department of Surgery, Nagoya City University, Nagoya, Japan
    • the Department of Hematology/Oncology, Polish-American Children's Hospital, Krakow, Poland.
    • ,
  • S Sasaki

      Affiliations

    • Department of Pathology, National Children's Hospital, Tokyo, Japan
    • Department of Surgery, National Children's Hospital, Tokyo, Japan
    • the Department of Pathology, University of Tokyo, Tokyo, Japan
    • the Department of Pediatric Surgery, University of Tokyo, Tokyo, Japan
    • the Department Pediatrics, University of Tokyo, Tokyo, Japan
    • the 2nd Department of Surgery, Nagoya City University, Nagoya, Japan
    • the Department of Hematology/Oncology, Polish-American Children's Hospital, Krakow, Poland.
    • ,
  • J Melanowska

      Affiliations

    • Department of Pathology, National Children's Hospital, Tokyo, Japan
    • Department of Surgery, National Children's Hospital, Tokyo, Japan
    • the Department of Pathology, University of Tokyo, Tokyo, Japan
    • the Department of Pediatric Surgery, University of Tokyo, Tokyo, Japan
    • the Department Pediatrics, University of Tokyo, Tokyo, Japan
    • the 2nd Department of Surgery, Nagoya City University, Nagoya, Japan
    • the Department of Hematology/Oncology, Polish-American Children's Hospital, Krakow, Poland.
    • ,
  • Y Tsuchida

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Y. Tsuchida, MD, Director, Gunma Children's Medical Center, 779 Shimohakoda, Hokkitsu, Seta-gun, Gunma 377, Japan.
    • Department of Pathology, National Children's Hospital, Tokyo, Japan
    • Department of Surgery, National Children's Hospital, Tokyo, Japan
    • the Department of Pathology, University of Tokyo, Tokyo, Japan
    • the Department of Pediatric Surgery, University of Tokyo, Tokyo, Japan
    • the Department Pediatrics, University of Tokyo, Tokyo, Japan
    • the 2nd Department of Surgery, Nagoya City University, Nagoya, Japan
    • the Department of Hematology/Oncology, Polish-American Children's Hospital, Krakow, Poland.

References 

  1. Belthold F, Utsch S, Holschneider AM. The impact of preoperative chemotherapy on resectability of primary tumor and complication rate in metastatic neuroblastoma. Z Kinderchir. 1989;44:21–24
  2. Grosfeld J, Baehner RL. Neuroblastoma: An analysis of 160 cases. World J Surg. 1980;4:29–38
  3. Kieley EM. The surgical challenge of neuroblastoma. J Pediatr Surg. 1994;29:128–133
  4. Matsumura M, Atkinson JB, Hays DM, et al.  An evaluation of surgery in metastatic neuroblastoma. J Pediatr Surg. 1988;23:448–453
  5. Tsuchida Y, Yokoyama J, Kaneko M, et al.  Therapeutic significance of surgery in advanced neuroblastoma: A report from the Study Group of Japan. J Pediatr Surg. 1992;27:616–622
  6. Haase GM, Wong KY, deLorimier AA, et al.  Improvement in survival after excision of primary tumor in stage III neuroblastoma. J Pediatr Surg. 1989;24:194–200
  7. Yokoyama J, Ikawa H, Endow M, et al.  The role of surgery in advanced neuroblastoma. Eur J Pediatr Surg. 1996;5:23–26
  8. Sawaguchi S, Kaneko M, Uchino J, et al.  Treatment of advanced neuroblastoma with emphasis on intensive induction chemotherapy: A report from the Study Group of Japan. Cancer. 1990;66:1879–1887
  9. Iwafuchi M, Utsumi J, Tsuchida Y, et al.  Evaluation of patients with advanced neuroblastoma surviving more than 5 years after initiation of an intensive Japanese protocol: A report from the Study Group of Japan. Med Pediatr Oncol. 1996;27:515–520
  10. Tsuchida Y, Honna T, Kamii Y, et al.  Radical excision of primary tumor and lymph nodes in advanced neuroblastoma: Combination with intensive induction chemotherapy. Pediatr Surg Int. 1991;6:22–27
  11. In: Japanese Society of Pathology, Committee on Histological Classification of Childhood Tumors  editors. Tumors in Infancy and Childhood III, Tumors of Neural Crest Origin. 1st ed.. Tokyo: Kanehara Shuppan; 1992;p. 1–88
  12. Haase GM, O'Leary M, Ramsey NKC, et al.  Aggressive surgery combined with intensive chemotherapy improves survival in poor-risk neuroblastoma. J Pediatr Surg. 1991;26:1119–1124
  13. LaQuaglia MP, Kushner BH, Heller G, et al.  Stage IV neuroblastoma diagnosed at more than 1 year of age: Gross total resection and clinical outcome. J Pediatr Surg. 1994;29:1162–1166
  14. Shamberger RC, Allarde-Segundo A, Kozakewitch HPW, et al.  Surgical management of stage III and IV neuroblastoma: Resection before or after chemotherapy?. J Pediatr Surg. 1991;26:1113–1118
  15. Ikeda H, August CS, Goldwein JW, et al.  Site of relapse in patients with neuroblastoma following bone marrow transplantation in relation to preoperative “debulking” treatment. J Pediatr Surg. 1992;27:1438–1441
  16. Kushner BH, LaQuaglia , Bonilla MA, et al.  Highly effective induction therapy for stage 4 neuroblastoma in children over 1 year of age. J Clin Oncol. 1994;12:2607–2613
  17. Kaneko M, Nishihira H, Mugishima H, et al: Results of advanced neuroblastoma with stratification into different protocols according to the degree of N-myc amplification. Med Pediatr Oncol (in press)

☆ Presented at the 30th Annual Meeting of the Pacific Association of Pediatric Surgeons, Phoenix, Arizona, May 9–13, 1997.

☆☆ This work was supported by Grants-in-Aid for Cancer Research (7–31 and 9–14) from the Ministry of Health and Welfare of the Government of Japan.

PII: S0022-3468(97)90467-X

Journal of Pediatric Surgery
Volume 32, Issue 11 , Pages 1620-1623 , November 1997

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