Journal of Pediatric Surgery
Volume 33, Issue 2 , Pages 299-303 , February 1998

The plug-unplug sequence: An important step to achieve type II pneumocyte maturation in the fetal lamb model

  • Hélène Flageole

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Hélène Flageole, MD, FRCSC, Montreal Children's Hospital, 2300 Tupper St, C-1129, Montreal, QC, Canada H3H 1P3.
    • Montreal Children's Hospital, Department of Surgery, McGill University, Montreal, Canada
    • Center for Surgical Technologies, Faculty of Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    • the Centre Hospitalier Universitaire Laval, Department of Pediatrics, Quebec, Canada.
    • HF is recipient of a doctoral scholarship from the Research Council of the K.U. Leuven, JD, VE are recipients of research fellowships from the Faculty of Medicine of the K.U. Leuven.
    • ,
  • Veerle A Evrard

      Affiliations

    • Montreal Children's Hospital, Department of Surgery, McGill University, Montreal, Canada
    • Center for Surgical Technologies, Faculty of Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    • the Centre Hospitalier Universitaire Laval, Department of Pediatrics, Quebec, Canada.
    • ,
  • Bruno Piedboeuf

      Affiliations

    • Montreal Children's Hospital, Department of Surgery, McGill University, Montreal, Canada
    • Center for Surgical Technologies, Faculty of Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    • the Centre Hospitalier Universitaire Laval, Department of Pediatrics, Quebec, Canada.
    • ,
  • Jean-Martin Laberge

      Affiliations

    • Montreal Children's Hospital, Department of Surgery, McGill University, Montreal, Canada
    • Center for Surgical Technologies, Faculty of Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    • the Centre Hospitalier Universitaire Laval, Department of Pediatrics, Quebec, Canada.
    • ,
  • Tony E Lerut

      Affiliations

    • Montreal Children's Hospital, Department of Surgery, McGill University, Montreal, Canada
    • Center for Surgical Technologies, Faculty of Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    • the Centre Hospitalier Universitaire Laval, Department of Pediatrics, Quebec, Canada.
    • ,
  • Jan A.M Deprest

      Affiliations

    • Montreal Children's Hospital, Department of Surgery, McGill University, Montreal, Canada
    • Center for Surgical Technologies, Faculty of Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    • the Centre Hospitalier Universitaire Laval, Department of Pediatrics, Quebec, Canada.

References 

  1. Alcorn D, Adamson TM, Lambert TH. Morphologic effects of chronic tracheal ligation and drainage in the fetal lamb lung. J Anat. 1977;123:649–660
  2. Piedboeuf B, Laberge JM, Gamache M, et al.  Deleterious effects of tracheal obstruction on type II pneumocytes in the fetal sheep. Pediatr Res. 1997;41:473–479
  3. O'Toole SJ, Karamanoukian HL, Williams DL, et al.  In utero lung distension decreases surfactant protein gene expression. Am J Respir Crit Care Med. 1996;153:A641
  4. Bullard K, Sonne J, Hawgood S, et al.  Tracheal ligation increases cell proliferation but decreases surfactant protein in fetal murine lungs in vitro. J Pediatr Surg. 1997;32:207–211
  5. Flageole H, Evrard VA, Vandenberghe K, et al.  Tracheoscopic tracheal occlusion in the ovine model: Possible application in congenital diaphragmatic hernia. J Pediatr Surg. 1997;32:1328–1331
  6. Tyler WS. Small airways and terminal units. Comparative subgross anatomy of lungs, pleuras, interlobular septa, and distal airways. Supplement comparative biology of the lung. Am Rev Resp Dis. 1983;128:S32–S36
  7. Dolhnikoff M, Dallaire M, Ludwig MS. Lung tissue distortion in response to methacholine in rats: Effect of lung volume. J Appl. Physiol. 1995;79:533–538
  8. Piedboeuf B, Johnston CJ, Watkins RH, et al.  Increased expression of tissue inhibitor of metalloproteinases (TIMP-I) and metallothionein in murine lungs after hyperoxic exposure. Am J Respir Cell Mol Biol. 1994;10:123–132
  9. Lund DP, Mitchell J, Kharasch V, et al.  Congenital diaphragmatic hernia: The hidden morbidity. J Pediatr Surg. 1994;29:258–262
  10. Harrison MR, Adzick NS, Flake AW, et al.  Correction of congenital diaphragmatic hernia in utero: VI. Hard-learned lessons. J Pediatr Surg. 1993;28:1411–1418
  11. Antunes MJ, Greenspan JS, Cullen JA, et al.  Prognosis with preoperative pulmonary function and lung volume assessment in infants with congenital diaphragmatic hernia. Pediatrics. 1995;96:1117–1122
  12. DiFiore JW, Fauza DO, Slavin R, et al.  Experimental fetal tracheal ligation reverses the structural and physiological effects of pulmonary hypoplasia in congenital diaphragmatic hernia. J Pediatr Surg. 1994;29:248–257
  13. Hashim E, Laberge JM, Chen MF, et al.  Reversible tracheal obstruction in the fetal sheep: Effects of tracheal fluid pressure and lung growth. J Pediatr Surg. 1995;30:1172–1177
  14. DiFiore JW, Fauza DO, Slavin R, et al.  Experimental fetal tracheal ligation and congenital diaphragmatic hernia: A pulmonary vascular morphometric analysis. J Pediatr Surg. 1995;30:917–924
  15. Finkelstein JN. Physiological and toxicologic responses of alveolar type II cells. Toxicol. 1990;60:41–52
  16. Hagwood S, Clements JA. Pulmonary surfactant and its apoproteins. J Clin Invest. 1990;86:1–6
  17. Horowitz S, Watkins RH, Auten R, et al.  Differential accumulation of surfactant protein A, B, and C mRNAs in two epithelial cell types on hyperoxic lungs. Am J Respir Cell Mol Biol. 1991;5:511–515
  18. BinSaddiq W, Piedboeuf B, Laberge JM, et al.  The effects of tracheal obstruction and release on type II pneumocytes in fetal lambs. In: Presented at the Canadian Association of Pediatric Surgeons. Halifax, Canada. August 1996;
  19. Deneke SM, Fanburg BL. Normobaric oxygen toxicity of the lung. N Engl J Med. 1980;303:76–86
  20. Luks FI, Deprest JA, Vendenberghe K, et al.  Fetoscopy-guided fetal endoscopy in a sheep model. J Am Coll Surg. 1994;178:609–612
  21. Luks FI, Deprest JA, Vandenberghe K, et al.  A model for fetal surgery through intrauterine endoscopy. J Pediatr Surg. 1994;29:1007–1009

☆ Presented at the 28th Annual Meeting of the American Pediatric Surgical Association, Naples, Florida, May 18–21, 1997.

☆☆ Supported in part by the Belgian National Foundation for Scientific Research, (N.F.W.O.) Grants, no 3.0122.94 and G.0190.96.

PII: S0022-3468(98)90451-1

Journal of Pediatric Surgery
Volume 33, Issue 2 , Pages 299-303 , February 1998

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