Journal of Pediatric Surgery
Volume 33, Issue 2 , Pages 312-316 , February 1998

Epidermal integrin expression is upregulated rapidly in human fetal wound repair

  • Darrell L Cass

      Affiliations

    • Children's Institute for Surgical Science, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
    • the University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
    • ,
  • Kelli M Bullard

      Affiliations

    • Children's Institute for Surgical Science, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
    • the University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
    • ,
  • Karl G Sylvester

      Affiliations

    • Children's Institute for Surgical Science, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
    • the University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
    • ,
  • Edmund Y Yang

      Affiliations

    • Children's Institute for Surgical Science, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
    • the University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
    • ,
  • Dean Sheppard

      Affiliations

    • Children's Institute for Surgical Science, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
    • the University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
    • ,
  • Meenhard Herlyn

      Affiliations

    • Children's Institute for Surgical Science, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
    • the University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
    • ,
  • N.Scott Adzick

      Affiliations

    • Corresponding Author InformationAddress reprint requests to N. Scott Adzick, MD, The Children's Hospital of Philadelphia, 34th St and Civic Center Blvd, Philadelphia, PA 19104.
    • Children's Institute for Surgical Science, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
    • the University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

References 

  1. Cass DL, Adzick NS. Fetal wound healing renaissance. Oral Maxillofacial Clinics. 1996;8:535–546
  2. Grinnell F. Wound repair, keratinocyte activation and integrin modulation. J Cell Science. 1992;101:1–5
  3. Longaker MT, Whitby DJ, Ferguson MWJ, et al.  Studies in fetal wound healing: III. Early deposition of fibronectin distinguishes fetal from adult wound healing. J Pediatr Surg. 1989;24:799–805
  4. Whitby DJ, Longaker MT, Brown L, et al.  Expression of alternatively spliced fibronectin mRNA during fetal wound healing. Surg Forum. 1995;46:644–646
  5. Whitby DJ, Longaker MT, Harrison MR, et al.  Rapid epithelialization of fetal wounds is associated with early deposition of tenascin. J Cell Science. 1991;99:583–586
  6. Longaker MT, Whitby DJ, Adzick NS, et al.  Studies in fetal wound healing. VI. Second and early third trimester fetal wounds demonstrate rapid collagen deposition without scar formation. J Pediatr Surg. 1990;25:63–69
  7. Sheppard D. Epithelial integrins. Bioessays. 1996;18:655–660
  8. Lorenz HP, Longaker MT, Perkocha LA, et al.  Scarless wound repair: A human fetal skin model. Development. 1992;114:253–259
  9. Hertle MD, Adams JC, Watt FM. Integrin expression during human epidermal development in vivo and in vitro. Development. 1991;112:193–206
  10. Hergott GJ, Nagai H, Kalnins VI. Inhibition of retinal pigment epithelial cell migration and proliferation with monoclonal antibodies against the β1 integrin subunit during wound healing in organ culture. Invest Ophthalmol Vis Sci. 1993;34:2761–2768
  11. Clark RAF. Fibronectin matrix deposition and fibronectin receptor expression in healing and normal skin. J Invest Dermatol. 1990;94:128S–134S
  12. Juhasz I, Murphy GF, Yan H-C, et al.  Regulation of extracellular matrix proteins and integrin cell substratum adhesion receptors on epithelium during cutaneous human wound healing in vivo. Am J Pathol. 1993;143:1458–1469
  13. Zambruno G, Cavani A, Manca V, et al.  Integrin expression during wound healing in human skin transplanted onto nude mice. J Invest Dermatol. 1991;96:1015; (abstr)
  14. Gailit J, Welch M, Clark RAF. TGF-β1 stimulates expression of keratinocyte integrins during re-epithelializatin of cutaneous wounds. J Invest Dermatol. 1994;103:221–227
  15. Klein S, Giancotti FG, Presta M, et al.  Basic fibroblast growth factor modulates integrin expression in microvascular endothelial cells. Mol Biol Cell. 1993;4:973–982
  16. Hertle MD, Jones PH, Groves RW, et al.  Integrin expression by human epidermal keratinocytes can be modulated by interferon-γ, transforming growth factor-β, tumor necrosis factor-α, and culture on a dermal equivalent. J Invest Dermatol. 1995;104:260–265
  17. Streuli CH, Schmidhauser C, Kobrin M, et al.  Extracellular matrix regulates expression of the TGF-β1 gene. J Cell Biol. 1993;120:253–260
  18. Werb Z, Tremble P, Behrendtsen O, et al.  Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression. J Cell Biol. 1989;109:877–889
  19. Langholz O, Rockel D, Mauch C, et al.  Collagen and collagenase gene expression in three-dimensional collagen lattices are differentially regulated by α1β1 and α2β1 integrins. J Cell Biology. 1995;131:1903–1915
  20. Huang X-Z, Wu JF, Cass D, et al.  Inactivation of the integrin β6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lungs and skin. J Cell Biol. 1996;133:921–928

☆ Presented at the 28th Annual Meeting of the American Pediatric Surgical Association, Naples, Florida, May 18–21, 1997.

☆☆ Supported by NIH grant HD 25505 (NSA) and a Postdoctoral Fellowship award from the Juvenile Diabetes Foundation International (DLC).

PII: S0022-3468(98)90453-5

Journal of Pediatric Surgery
Volume 33, Issue 2 , Pages 312-316 , February 1998

Article Tools