Journal of Pediatric Surgery
Volume 34, Issue 11 , Pages 1606-1609 , November 1999

Expression of RET proto-oncogene and GDNF deficit in Hirschsprung's disease

  • Jianghua Zhan

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Jianghua Zhan, MD, Department of Pediatric Surgery, Tianjin Children's Hospital, Tianjin 300074, China.
    • Department of Surgery, Tianjin Children's Hospital, Tianjin, China.
    • Department of Pathology, Tianjin Children's Hospital, Tianjin, China.
    • the Laboratory of Molecular Genetics, Tianjin Medical University, Tianjin, China.
    • ,
  • Yao Xiu

      Affiliations

    • Department of Surgery, Tianjin Children's Hospital, Tianjin, China.
    • Department of Pathology, Tianjin Children's Hospital, Tianjin, China.
    • the Laboratory of Molecular Genetics, Tianjin Medical University, Tianjin, China.
    • ,
  • Jiqing Gu

      Affiliations

    • Department of Surgery, Tianjin Children's Hospital, Tianjin, China.
    • Department of Pathology, Tianjin Children's Hospital, Tianjin, China.
    • the Laboratory of Molecular Genetics, Tianjin Medical University, Tianjin, China.
    • ,
  • Zhichin Fang

      Affiliations

    • Department of Surgery, Tianjin Children's Hospital, Tianjin, China.
    • Department of Pathology, Tianjin Children's Hospital, Tianjin, China.
    • the Laboratory of Molecular Genetics, Tianjin Medical University, Tianjin, China.
    • ,
  • XiaoLi Hu

      Affiliations

    • Department of Surgery, Tianjin Children's Hospital, Tianjin, China.
    • Department of Pathology, Tianjin Children's Hospital, Tianjin, China.
    • the Laboratory of Molecular Genetics, Tianjin Medical University, Tianjin, China.

References 

  1. Schuchardt AD, Agati V, Larsson-Blombery L, et al.  Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor. Nature. 1994;367:380–383
  2. Kusafuka T, Wang Y, Puri P. Mutation analysis of the RET, the endothelin-B receptor and the endothelin-3 genes in sporadic cases of Hirschsprung's disease. J Pediatr Surg. 1997;32:501–504
  3. Trupp M, Arenas E, Fainzilber M, et al.  Functional receptor for GDNF encoded by the c-ret proto-oncogene. Nature. 1996;381:785–788
  4. Lin LF, Doherty DH, Lile JD, et al.  GDNF: A glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science. 1993;260:1130–1132
  5. Ohshiro K, Puri P. Reduced glial cell lined-derived neurotrophic factor level in aganglionic bowel in Hirschsprung's disease. J Pediatr Surg. 1998;33:904–908
  6. Earlam R. A vascular cause for Hirschsprung's disease?. Gastroenterology. 1985;88:1274–1279
  7. Fujimoto T, Hata J, Yokoyama S, et al.  A study of the extracellular matrix protein as the migration pathway of neural crest cells in the gut: Analysis in human embryos with apecial reference to the pathogenesis of Hirschsprung's disease. J Pediatr Surg. 1989;24:550–556
  8. Parikh DH, Tam PKH, Leoyd DA, et al.  Quantitative and qualitative analysis of the extracellular matrix protein, laminin, in Hirschsprung's disease. J Pediatr Surg. 1992;27:991–996
  9. Jacobs-Cohen RJ, Payette PF, Gershon MD, et al.  Inability of neural crest cells to colonize, the presumptive aganglionic bowel of mutant mice: Requirements for a permissive microenvironment. J Comp Neurol. 1987;225:425–438
  10. Zhan JH, Fang ZQ, Gu J. Expression of RET proto-oncogene in Hirschsprung's disease. Chin J Pediatr Surg. 1999;20:5–6
  11. Van-Heyningen V. Genetics: One gene-four syndromes. Nature. 1994;367:319–320
  12. Remeo G, Ronchetto P, Luo Y, et al.  Point mutations affecting the tyrosine kinase domain of the RET proto-oncogene in Hirschsprung's disease. Nature. 1994;367:377–378
  13. Kusafuka T, Puri P. Altered RET gene mRNA expression in Hirschsprung's disease. J Pediatr Surg. 1997;32:600–604
  14. Henderson CE, Phillips HS, Pollock PA, et al.  GDNF: A potent survival factor for motoneurons in peripheral nerve and muscle. Science. 1994;266:1062–1064
  15. Zurn AD, Baetge EE, Hammang JP, et al.  Glial cell line-derived neurotrophic factor (GDNF), a new neurotrophic factor for motoneurons. Neuroreport. 1994;6:113–118
  16. Yan Q, Matheson C, Lopez OT. In vivo neurotrophic effects of GDNF in neonatal and adult facial motor neurons. Nature. 1995;373:341–344
  17. Martucciello G, Thompson H, Mazzola C, et al.  GDNF deficit in Hirschsprung's disease. J Pediatr Surg. 1998;33:99–102
  18. Pachnis V, Mankoo B, Costanitini F. Expression of the c-ret proto-oncogene during mouse embryogenesis. Development. 1993;119:1005–1017
  19. Hellmich HL, Kos L, Cho ES, et al.  Embryonic expression of glial cell line derived neurotrophic factor(GDNF) suggests multiple developmental roles in neural differentiation and epithelial-mesenchymal interactions. Mech Dev. 1996;54:95–105

☆ Presented at the 32th Annual Meeting of the Pacific Association of Pediatric Surgeons, Beijing, China, May 9–14, 1999.

PII: S0022-3468(99)90626-7

Journal of Pediatric Surgery
Volume 34, Issue 11 , Pages 1606-1609 , November 1999

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