Focal nodular hyperplasia of the liver: usefulness of superparamagnetic iron oxide–enhanced magnetic resonance imaging


      This report describes the use of superparamagnetic iron oxide–enchanced magnetic resonance imaging to diagnose fibronodular hyperplasia of the liver in a 12-year-old girl.

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        • Feng C.Y.
        • Lai H.S.
        • Huang S.F.
        Focal nodular hyperplasia of the liver in a child.
        J. Formos. Med. Assoc. 2000; 99: 870-872
        • Reymond D.
        • Plaschkes J.
        • Lűthy A.R.
        • et al.
        Focal nodular hyperplasia of the liver in children: review of follow-up and outcome.
        J. Pediatr. Surg. 1995; 30: 1590-1593
        • Cheon J.E.
        • Kim W.S.
        • Kim I.O.
        • et al.
        Radiological features of focal nodular hyperplasia of the liver in children.
        Pediatr. Radiol. 1998; 28: 878-883
        • Poeckler-Schoeniger C.
        • Koepke J.
        • Gueckel F.
        • et al.
        MRI with superparamagnetic iron oxide: efficacy in the detection and characterization of focal hepatic lesions.
        Magn. Reson. Imaging. 1999; 17: 383-392
        • Ichikawa T.
        • Arbab A.S.
        • Araki T.
        • et al.
        Perfusion MR imaging with a superparamagnetic iron oxide using T2-weighted and susceptibility-sensitive echoplanar sequences: evaluation of tumor vascularity in hepatocellular carcinoma.
        AJR. 1999; 173: 207-213
        • Paley M.R.
        • Mergo P.J.
        • Torres G.M.
        • et al.
        Characterization of focal hepatic lesions with ferumoxides-enhanced T2-weighted MR imaging.
        AJR. 2000; 175: 159-163
        • Reimer P.
        • Jähnke N.
        • Fiebich M.
        • et al.
        Hepatic lesion detection and characterization: value of nonenhanced MR imaging, superparamagnetic iron oxide–enhanced MR imaging, and spiral CT-ROC analysis.
        Radiology. 2000; 217: 152-158
        • Kim J.H.
        • Kim M.J.
        • Suh S.H.
        • et al.
        Characterization of focal hepatic lesions with ferumoxides-enhanced MR imagings: utility of T1-weighted spoiled gradient recalled echo images using different echo times.
        J. Magn. Reson. Imaging. 2002; 15: 573-583
        • Tanimoto A.
        • Yuasa Y.
        • Shinmoto H.
        • et al.
        Superparamagnetic iron oxide–mediated hepatic signal intensity change in patients with and without cirrhosis: pulse sequence effects and Kupffer cell function.
        Radiology. 2002; 222: 661-666
        • Wang Y.X.J.
        • Hussain S.H.
        • Krestin G.P.
        Superparamagnetic iron oxide contrast agents: physicochemical characteristics and applications in MR imagings.
        Eur. Radiol. 2001; 11: 2319-2331
        • Beets-Tan R.G.H.
        • Engelshoven J.M.A.
        • Greve J.W.M.
        Hepatic adenoma and focal nodular hyperplasia: MR findings with superparamagnetic iron oxide–enhanced MRI.
        Clin. Imaging. 1998; 22: 211-215
        • Henrik E.
        • Hart I.
        • Hossein G.M.
        Benign liver tumor in infancy and childhood.
        Am. J. Surg. 1983; 145: 325-329
        • Nichols F.C.
        • Heerden J.A.
        • Weiland L.H.
        Benign liver tumors.
        Surg. Clin. North Am. 1989; 69: 297-314
        • Nadimibie O.K.
        • Goodman Z.D.
        • Chase R.L.
        • et al.
        Hemangiomas with localized nodular proliferation of the liver: a suggestion on the pathogenesis of focal nodular hyperplasia.
        Am. J. Surg. Pathol. 1990; 14: 142-150
        • Knowles D.M.
        • Wolff M.
        Focal nodular hyperplasia of the liver: a clinicopathologic study and review of the literature.
        Hum. Pathol. 1976; 7: 533-545
        • Stocker J.T.
        • Ishak K.G.
        Focal nodular hyperplasia of the liver: a study of 21 pediatric cases.
        Cancer. 1981; 48: 336-345
        • Bouyn C.I.
        • Leclere J.
        • Raimondo G.
        • et al.
        Hepatic focal nodular hyperplasia in children previously treated for a solid tumor: incidence, risk factors, and outcome.
        Cancer. 2003; 97: 3107-3113
        • Shamsi K.
        • Schepper A.
        • Degryse H.
        • et al.
        Focal nodular hyperplasia of the liver: radiological findings.
        Abdom. Imaging. 1993; 18: 32-38
        • Somech R.
        • Brazowski E.
        • Kesller A.
        • et al.
        Focal nodular hyperplasia in children.
        J. Pediatr. Gastroenterol. Nutr. 2001; 32: 480-483
        • Seneterre E.
        • Taourel P.
        • Bouvier Y.
        • et al.
        Detection of hepatic metastasis: ferumoxides-enhanced MR imaging versus unenhanced MR imaging and CT during arterial portography.
        Radiology. 1996; 200: 785-792
        • Grossholz M.
        • Terrier F.
        Enhancement of liver hemangiomas on T1-weighted MR SE images by superparamagnetic iron oxide particles.
        J. Comput. Assist. Tomogr. 1994; 18: 888-896
        • Harisinghani M.G.
        • Saini S.
        • Weissleder R.
        • et al.
        Differentiation of liver hemangiomas from metastases and hepatocellular carcinoma at MR imaging enhanced with blood-pool contrast agent Code-7227.
        Radiology. 1997; 202: 687-691
        • Evans J.E.
        • Dick R.
        • Sherlock S.
        • et al.
        Focal nodular hyperplasia of the liver.
        Br. J. Surg. 1980; 67: 175-177
        • Stasi M.D.
        • Caturelli E.
        • Sio I.D.
        • et al.
        Natural history of focal nodular hyperplasia of the liver: an ultrasound study.
        J. Clin. Ultrasound. 1996; 24: 345-350