Abstract
The authors describe a newborn patient with mesenchymal hamartoma of the chest wall
associated with pulmonary hypoplasia. A massive thoracic tumor was diagnosed by prenatal
ultrasonography and magnetic resonance imaging at the 28th week of gestation. She
was delivered through cesarean delivery at the 36th gestational week. Respiratory
distress because of pulmonary hypoplasia necessitated neonatal intensive care. The
tumor extensively involved the left hemithorax including all 12 ribs and the first
10 thoracic vertebrae, resulting in marked deformity of the thorax. At 5 days of age,
she underwent the incisional biopsy through a left thoracotomy. Histopathology of
biopsy specimens showed multiple components of mesenchymal origin including premature
cartilage, bone, and cystic lesions resembling aneurysmal bone cyst. The tumor then
showed a rapid overgrowth, but subsequently exhibited a self-limited growth for months,
in which her respiratory condition gradually improved to spontaneous breathing without
oxygenation support. The present case advocates perinatal preparations for associated
pulmonary hypoplasia and conservative management for the neoplasm in fetuses prenatally
diagnosed as having this unique pathological entity.
Index words
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of Pediatric SurgeryAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Chest wall tumors in infancy and childhood.Cancer. 1989; 63: 774-785
- Chest wall mesenchymoma (hamartoma) in infancy. CT and MR findings.Pediatr. Radiol. 1989; 19: 212-213
- Hamartomas of the chest wall in infants.Ann. Thorac. Surg. 1994; 57: 868-875
- Conservative management of mesenchymal hamartomas of the chest wall.J. Pediatr. Surg. 2001; 36: 1346-1349
- Infantile chest hamartoma—case outcome aged 11.Arch. Dis. Child. 2001; 85: 244-245
- Chest wall hamartoma in infancy: a case report with immunohistochemical analysis of various interstitial collagen types.Pediatr. Pathol. 1994; 14: 3-9
- Infantile cartilaginous hamartoma of the rib. A case report.Acta Cytol. 2001; 45: 69-73
- Surgical management of the infant with mesenchymal hamartoma of the chest wall.J. Pediatr. Surg. 1986; 21: 556-558
- Hamartoma (mesenchymoma) of the chest wall in infancy.Radiology. 1979; 131: 657-661
- Mesenchymal hamartoma of the chest wall.J. Am. Coll. Surg. 2001; 193: 329
- Prenatal diagnosis and the pediatric surgeon: the impact of prenatal consultation on perinatal management.J. Pediatr. Surg. 1996; 31: 156-162
- Mesenchymal hamartoma of the chest wall: radiologic manifestations with emphasis on cross-sectional imaging and histopathologic comparison.Radiology. 2002; 222: 205-211
- Thoracic mesenchymoma of infancy.J. Pediatr. Surg. 1996; 31: 726-728
Article info
Footnotes
This work was supported by the Scientific Research Fund of the Ministry of Education, Science and Culture of Japan (no. 13557146).
Identification
Copyright
© 2005 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
