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In previous reports, anastomosis has been shown to disrupt the myoelectric activity
of the bowel. However, these studies have failed to delineate the role of the extrinsic
nerves. Using an isolated bowel segment (IBS) and an amesenteric bowel segment (ABS),
motility was evaluated by myoelectric recording across a bowel anastomosis. Ten rats
were divided equally into the experimental group with the IBS and the control group
with the ABS. In the IBS group, an 8-cm segment of jejunum was divided, reanastomosed,
and coapted to the liver margin (lowa model II). In the ABS group, an 8-cm segment
of jejunum was coapted to the liver margin without disruption of bowel continuity
(lowa modell II variant). Two weeks later, bipolar electrodes were implanted in the
IBS and ABS, and normal jejunum in both groups. Mesenteric division (MD) was performed
4 weeks later to eliminate extrinsic innervation. Myoelectrical recordings were taken
2 weeks before and after MD. In the control group with IBS, incoordination in the
propagation of the migrating motor complex (MMC) and reduction in the frequency of
slow waves (FSW) were observed across the anastomosis and were unchanged by MD. In
the control group with the ABS, the MMC and FSW were identical to that in the normal
jejunum and were unaffected by MD. In both group postprandial inhibition of the MMC
was the same as in the normal jejunum and was unaffected by MD. This study confirms
that incoordination in propagation of the MMC and reduction in FSW occur across a
bowel anastomosis, and elimination of extrinsic innervation does not affect the autonomy
of these changes. Postprandial inhibition of the MMC does not appear to be affected
by intramural discontinuity or elimination of extrinsic innervation.
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Article info
Footnotes
*Presented at the 24th Annual Meeting of the Pacific Association of Pediatric Surgeons, Hong Kong, May 20–24, 1991.
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Copyright
© 1992 W.B. Saunders Company. All right reserved. Published by Elsevier Inc.
