Abstract
Background/Purpose
Previous work has shown that intrapulmonary delivery of oncotic agents enhance overall
lung growth after late gestational fetal tracheal occlusion (TO). This study was a
post hoc analysis aimed at determining whether actual alveolar and capillary hyperplasias
are maximized in this setting.
Methods
Twenty-one near term fetal lambs were evenly divided into 4 groups: group I comprised
sham-operated controls; group II had TO alone; and groups III and IV underwent TO
and intratracheal infusion of equal amounts of either saline or 25% albumin, respectively.
Approximately 2 weeks thereafter, their lungs were examined by detailed alveolar and
capillary morphometry before birth. Statistical analysis included analysis of variance
and the Bonferroni correction for multiple comparisons (P < .05).
Results
Total alveolar and capillary numbers, as well as total alveolar surface area, were
significantly higher in group IV and lower in group I compared with all other groups,
with no differences between groups II and III. Alveolar capillary load was normal
in all groups.
Conclusions
Intrapulmonary delivery of concentrated albumin safely enhances short-term alveolar
and capillary hyperplasia in a late gestational model of fetal TO. This therapeutic
concept may allow for TO to be effective and predictable when performed late in gestation.
Index words
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Article info
Footnotes
☆SMK was supported by grants from the NIH National Research Service Award DK065406-02 and the VH Kazanjian Surgical Research Fellowship of the Massachusetts General Hospital.
Identification
Copyright
© 2006 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
