Abstract
Malacoplakia is a rare inflammatory condition characterized by demonstrative Michaelis-Gutmann
bodies, which are foamy histiocytes with distinctive basophilic inclusions. Malacoplakia
is caused by the inadequate elimination of bacteria by macrophages or monocytes as
a result of defective phagocytic activity. Xanthogranulomatous pyelonephritis is characterized
by the destruction of renal parenchyma and its replacement by solid sheets of foamy
lipid-laden macrophages. Prolonged infection of the kidney, which is frequently caused
by an obstruction of the urinary tract, is the pathologic mechanism of that condition.
We present a 6-year-old patient with a poorly functioning kidney who had a prolonged
recurrent urinary tract infection. The results of histologic analysis revealed an
inflammatory infiltration consisting predominantly of foamy and epithelioid histiocytes
that contained round intracytoplasmic concretions characteristic of Michaelis-Gutmann
bodies. We suggest that malacoplakia might be a stage of xanthogranulomatous pyelonephritis.
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© 2007 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
