Abstract
Background
Liver nodules have been reported after portal systemic shunt surgery (PSSS) in animal
experiments or in humans with liver cirrhosis. The aim of our study was to assess
the incidence of liver nodules after surgery for extrahepatic portal vein obstruction
(EHPVO) in children without associated liver disease.
Methods
We retrospectively reviewed the charts of 45 children who had surgery from 1979 to
2005 for EHPVO in our institution, consisting of 38 PSSS and 7 portal reperfusion
procedures (PRPs). We assessed the presence of liver nodules on ultrasonography.
Results
Of 45 patients, 7 (15%) had liver nodules during a median of 80 months of follow-up.
All the nodules occurred after PSSS. Five nodules were subjected to biopsy; we found
2 liver cell adenomas and 3 focal nodular hyperplasias.
Conclusions
In this study, liver nodules occurred in 18% of cases after PSSS for EHPVO in children
and not after PRP. As many children have undergone PSSS throughout the world, the
presence of liver nodules should be considered during the follow-up of those patients.
Key words
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Article info
Publication history
Accepted:
November 3,
2008
Received in revised form:
October 7,
2008
Received:
June 27,
2008
Identification
Copyright
© 2009 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
