Abstract
OK-432 therapy is effective for the treatment of macrocystic lymphatic malformations
(LMs), but the optimal management of patients with microcystic LMs associated with
large chylous pleural effusions or chylous ascites is not resolved. We performed thoracoscopic-
or laparoscopic-guided injection of OK-432 for 2 patients with diffuse microcystic
LMs accompanied by refractory chylous pleural effusion or chylous ascites. Both cases
responded well to OK-432 therapy with improvement/resolution of fluid collections
and associated symptoms. We recommend the use of OK-432 therapy as a promising treatment
for microcystic LMs with functionally significant lymphatic fluid collections.
Key words
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Article info
Publication history
Accepted:
June 7,
2010
Received in revised form:
May 30,
2010
Received:
December 9,
2009
Identification
Copyright
© 2010 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
