Long-term follow-up of a child with primary lymph node gastrinoma and Zollinger-Ellison syndrome

      Abstract

      A 10-year-old child with Zollinger-Ellison syndrome and primary lymph node gastrinoma is reported to emphasize the difficulties encountered in management and the value of long-term follow-up. The gastrinoma was present in a lymph node close to the greater curvature of the stomach. Primary lymph node gastrinomas are relatively rare in children and, to the best of our knowledge, have not previously been reported at this location.

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      References

        • Wolfe M.M.
        • Jensen R.T.
        Zollinger-Ellison syndrome—current concepts in diagnosis and managment.
        N Engl J Med. 1987; 317: 1200-1208
        • Ellison E.
        • Johnson J.A.
        The Zollinger-Ellison syndrome: a comprehensive review of historical, scientific and clinical considerations.
        Curr Probl Surg. 2009; 46: 13-106
        • Scherer L.R.
        Peptic ulcer and other conditions of the stomach.
        in: Grosfeld J.L. O'Neill J.A. Fonkalsrud E.W. Pediatric surgery. 6 ed. Mosby Elsevier, Philadelphia2006: 1238-1241
        • Furuta G.T.
        • Bloss R.S.
        • Lifschitz C.H.
        • et al.
        Colonic interposition after esophagogastrectomy in a child with Zollinger-Ellison syndrome.
        J pediatr Surg. 1989; 24: 1146-1148
        • Abe K.
        • Niikawa N.
        • Sasaki H.
        Zollinger-Ellison syndrome with Marden-Walker syndrome—association of two rare diseases in a 5-year-old girl.
        Am J Dis Child. 1979; 133: 735-738
        • Diaz R.
        • Aparicio J.
        • Pous S.
        • et al.
        Primary hepatic gastrinoma.
        Dig Dis Sci. 2003; 48: 1665-1667
        • Nord K.S.
        • Joshi V.
        • Hanna M.
        • et al.
        Zollinger-Ellison syndrome associated with a renal gastrinoma in a child.
        J Pediatr Gastroenterol Nutr. 1986; 5: 980-986
        • Croffie J.M.
        • Fitzgerald J.F.
        • Grosfeld J.L.
        • et al.
        Marked gastric mucosal hyperplasia without definite peptic ulceration related to a multifocal hepatic gastrinoma.
        J Pediatr Gastroenterol Nutr. 1994; 19: 315-321
        • Arnold W.S.
        • Fraker D.L.
        • Alexander R.
        • et al.
        Apparent lymph node primary gastrinoma.
        Surgery. 1994; 116: 1123-1130
        • Odelowo O.O.
        • Nidiry J.J.
        • Zulu S.H.
        Primary lymph node gastrinoma: a case report.
        J Nalt Med Assoc. 2003; 95: 168-171
        • Bornman P.C.
        • Marks I.N.
        • Mee A.S.
        • et al.
        Favourable response to conservative surgery for extra-pancreatic gastrinoma with lymph node metastases.
        Br J Surg. 1987; 74: 198-201
        • Farley D.R.
        • vanHeerden J.A.
        • Grant C.S.
        • et al.
        Extrapancreatic gastrinoma—surgical experience.
        Arch Surg. 1994; 129: 506-512
        • Thompson N.W.
        • Vinik A.I.
        • Eckhauser F.E.
        • et al.
        Extrapancreatic gastrinomas.
        Surgery. 1985; 98: 1113-1120
        • Friesen S.R.
        Are “aberrant nodal gastrinoma” pathogenetically similar to “lateral aberrant thyroid” nodules?.
        Surgery. 1990; 107: 236-238
        • Dall'lgna P.
        • Cecchetto G.
        • Bisogno G.
        • et al.
        Pancreatic tumors in children and adolescents: the Italian TREP project experience.
        Pediatr Blood Cancer. 2010; 54: 675-680
        • Wilson S.D.
        • Schulte W.J.
        • Meade R.C.
        Longevity studies following total gastrectomy in children with the Zollinger-Ellison syndrome.
        Arch Surg. 1971; 103: 108-115
        • Wilson S.D.
        Zollinger-Ellison syndrome in children: a 25-year follow up.
        Surgery. 1991; 110: 696-703
        • Passaro E.
        • Howard T.J.
        • Sawicki M.P.
        • et al.
        The origion of sporadic gastrinoma within the gastrinoma triangle—a theory.
        Arch Surg. 1998; 133: 13-16
        • Perrier N.D.
        • Batts K.P.
        • Thompson G.B.
        • et al.
        An immunohistchemical survey for neuroendocrine cells in regional pancreatic lymph nodes: a plausible explanation for primary nodal gastrinoma?.
        Surgery. 1995; 118: 957-966
        • Herrmann M.E.
        • Ciesla M.C.
        • Chejfec G.
        • et al.
        Primary nodal gastrinomas—an immunohistochemical study in support of a theory.
        Arch Pathol Lab Med. 2000; 124: 832-835
        • Norton J.A.
        • Alexander H.R.
        • Fraker D.L.
        • et al.
        Possible primary lymph node gastrinoma: occurance, natural history,and predictive factors—a prospective study.
        Ann Surg. 2003; 237: 650-659
        • Shi E.C.P.
        • Mitchell J.D.
        • Ham J.M.
        Antral G-cell hyperplasia (pseudo-Zollinger-Ellison syndrome) and chronic duodenal ulceration in a child.
        Pediatr Surg Int. 1987; 2: 311-314
        • Chang F.Y.
        • Liao K.Y.
        • Wu L.
        • et al.
        A uncommon cause of abdominal pain and diarrhoea-gastrinoma in an adolescent.
        Eur J Pediatr. 2010; 169: 355-357
        • Drake D.P.
        • Maciver A.
        • Atwell J.D.
        Zollinger-Ellison syndrome in a child: medical treatment with cimetidine.
        Arch Dis Child. 1980; 55: 226-238
        • Burmester H.B.C.
        • Hall R.
        • Munawar N.
        The Zollinger-Ellison syndrome in a child.
        Gut. 1969; 10: 800-803