Abstract
Only 2 cases of osteosarcoma as a second primary malignancy after neuroblastoma have
been reported in the literature. We present a case of chest wall osteosarcoma that
developed in a 14-year-old boy 7 years after completion of chemotherapy, autologous
peripheral blood stem cell transplantation, radiation, and resection for stage 3,
high-risk neuroblastoma. A biopsy of a painful chest wall mass arising from the right
third rib diagnosed osteosarcoma. He went on to have preoperative chemotherapy followed
by wide local excision and chest wall reconstruction. He then received additional
chemotherapy. This case highlights the importance of close observation for second
malignancies in this patient population.
Key words
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of Pediatric SurgeryAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Second malignant neoplasms after cancer in childhood and adolescence: a population-based case-control study in the 5 Nordic countries. The Nordic Society for Pediatric Hematology and Oncology. The Association of the Nordic Cancer Registries.Int J Cancer. 2000; 88: 672-678
- Osteosarcoma after chemotherapy for neuroblastoma.Skeletal Radiol. 1995; 24: 633-635
- Osteosarcoma as a second malignancy after treatment for neuroblastoma.Pediatr Hematol Oncol. 2001; 18: 465-469
- Osteosarcoma: ESMO clinical recommendations for diagnosis, treatment and follow-up.Ann Oncol. 2009; 20: 137-139
- Response and toxicity to a dose-intensive multi-agent chemotherapy induction regimen for high risk neuroblastoma (HR-NB): a Children's Oncology Group (COG A3973) study.J Clin Oncol. 2007; 25 (2007 ASO Annual Meeting Proceedings Part 1): 9505
- Osteosarcoma as a second malignant neoplasm in children.J Bone Joint Surg. 1992; 74: 1079-1083
- Forty-year experience with second malignancies after treatment of childhood cancer: analysis of outcome following the development of the second malignancy.J Pediatr Surg. 1993; 28: 1324-1349
- Second primary neoplasms in children.Am J Roentgenol Radium Ther Nucl Med. 1968; 103: 800-822
- Long-term risk of second malignant neoplasms after neuroblastoma in childhood: role of treatment.Int J Cancer. 2003; 107: 791-796
- Long-term complication in survivors of advanced stage neuroblastoma.Pediatr Blood Cancer. 2005; 45: 324-332
- Hepatoblastoma presenting with focal nodular hyperplasia after treatment of neuroblastoma.J Pediatr Surg. 2008; 43: 2297-2300
- Clear cell sarcoma of the gastrointestinal tract presenting as a second malignant neoplasm following neuroblastoma in infancy.Pediatr Blood Cancer. 2012; 58: 481-482
- Embryonal rhabdomyosarcoma as a second malignancy following multimodal therapy for advanced-stage neuroblastoma.Pediatr Radiol. 2008; 38: 1017-1020
- Radiation-associated malignant tumors of the chest wall.Ann Surg Oncol. 1996; 3: 387-392
- Chest wall tumors: radiologic findings and pathologic correlation: part 2. Malignant tumors.Radiographics. 2003; 23: 1491-1508
- Outcome for adolescent and young adult patients with osteosarcoma. A report from the Children's Oncology Group.Cancer. 2012; ([Epub ahead of print])
- Primary chest wall tumors: early and long-term results of surgical treatment.Eur J Cardiothorac Surg. 2001; 19: 589-593
- Novel titanium constructs for chest wall reconstruction in children.J Pediatr Surg. 2011; 46: 1005-1010
Article info
Publication history
Accepted:
April 26,
2012
Received in revised form:
April 17,
2012
Received:
January 4,
2012
Identification
Copyright
© 2012 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
