Abstract
Hepatoblastoma is the most common malignant liver tumor of infancy and presents most
frequently at a median age of 18 months. Presentation in the neonatal period is rare,
and there are very few reports of an antenatal diagnosis of hepatoblastoma. We recently
encountered a neonate who presented with hemoperitoneum after rupture of a congenital
hepatoblastoma during vaginal delivery. After successful right hepatectomy and adjuvant
cis-platinum–based chemotherapy, the child is doing well. We draw attention to rarity
of this condition and difficulty in definitively establishing a diagnosis both in
the antenatal and neonatal periods and discuss the management dilemmas in congenital
presentations of hepatoblastoma.
Key words
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of Pediatric SurgeryAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Liver tumors in children in the particular reference to hepatoblastoma and hepatocellular carcinoma: American Academy of Pediatrics Surgical Section Survey-1974.J Pediatr Surg. 1975; 10: 329-337
- Hepatic tumors.in: Reis L.A.G. Smith M.A. Gurney J.G. Cancer Incidence and Survival Among Children and Adolescents: United States SEER Program, 1975–1995. National Cancer Institute SEER Program. NIH Pub. No. 99–4649, Bethesda MD1999: 91-97
- Prenatal diagnosis of fetal hepatoblastoma with a good neonatal outcome: case report and narrative literature review.Pediatr Hematol Oncol. 2011; 288: 150-154
- Congenital hepatoblastoma: a distinct entity.Med Pediatr Oncol. 1999; 32: 466-468
- A prenatally detected case of congenital hepatoblastoma.Pathol. Onocol. Res. 2008; 14: 97-100
- Antenatal diagnosis of congenital hepatoblastoma in utero.Ultrasound Obstet Gynecol. 2000; 16: 94-97
- Prenatal diagnosis of fetal hepatoblastoma: case report and review of the literature.Ultrasound Med. 2008; 27: 1095-1098
- Elevated expression of wnt antagonists is a common event in hepatoblastomas.Clin Cancer Res. 2005; 11: 4295-4304
- Histologic subtypes of hepatoblastoma are characterized by differential canonical Wnt and Notch pathway activation in DLK+ precursors.Hum Pathol. Jun 2009; 40: 783-794
- Pre- and postnatal imaging of a congenital hepatoblastoma.Fetal Diagn Ther. 2011; 30: 157-159
- Fetal hepatoblastoma presenting as nonimmune hydrops.Am J Perinatol. 1989; 6: 278-280
- Placental involvement in congenital hepatoblastoma.Pediatr Dev Pathol. 1998; 1: 538-542
- Hepatoblastoma: a report of a case diagnosed in utero [in Spanish].An Esp Pediatr. 1993; 39: 265-267
- Prenatal imaging of fetal hepatoblastoma.J Matern Fetal Neonatal Med. 2005; 17: 157-159
- Neonatal hepatoblastoma: two cases posing a diagnostic dilemma, with a review of the literature.Am J Perinatol. 2005; 22: 413-419
- Epidemiological and familial aspects of hepatoblastoma.Med Pediatr Oncol. 1990; 18: 103-109
- The value of fast MR imaging as an adjunct to ultrasound in prenatal diagnosis.Eur Radiol. 2003; 13: 1538-1548
- Effects of residential distance to hospitals with neonatal surgery care on prenatal management of outcome of pregnancies with severe fetal malformations.Ultrasound Obstet Gynecol. 2007; 29: 271-275
Article info
Publication history
Accepted:
May 25,
2012
Received in revised form:
May 2,
2012
Received:
April 2,
2012
Identification
Copyright
© 2012 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
