Rapid Communication| Volume 47, ISSUE 11, e45-e48, November 2012

Hepatic mesenchymal hamartoma in a neonate with a Bochdalek diaphragmatic hernia: A case report


      The Bochdalek diaphragmatic hernia (BDH) is a common birth defect that is associated with other congenital malformations. Hepatic mesenchymal hamartoma (HMH) is the second most common benign hepatic tumor in children. The association between BDH and HMH or ectopic hepatic tissue is uncommon. We report a case of a female newborn with a left BDH that at surgery was incidentally found to have a tumor of 3.5 cm in maximum dimension with a serous muscular membrane. The histopathological study revealed vascular–mesenchymal stroma with bile ducts entrapped and peripheral normal hepatic tissue. These findings correlate with the diagnosis of hepatic mesenchymal hamartoma (HMH) in ectopic hepatic tissue. Our objective is to report a case of a rare association between HMH and BDH as well as discuss its differential diagnosis.

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        • Stoll C.
        • Alembic Y.
        • Dott B.
        • et al.
        Associated malformations in cases with congenital diaphragmatic hernia.
        Genet Couns. 2008; 19: 331-339
        • Masayuki S.
        • Kentaro W.
        Mesenchymal hamartoma of the liver: a proliferative lesion of possible hepatic stellate cell (Ito cell) origin.
        Pathol Res Pract. 2010; 206: 532-536
        • Baboiu O.E.
        • Saal H.
        • Collins M.
        Hepatic mesenchymal hamartoma: cytogenetic analysis of a case and review of the literature.
        Pediatr Dev Pathol. 2008; 11: 295-299
        • Stringer M.
        • Alizai N.
        Mesenchymal hamartoma of the liver: a systematic review.
        J Pediatr Surg. 2005; 40: 1681-1690
        • Gow K.W.
        • Lee L.
        • Pruthi S.
        • et al.
        Mesenchymal hamartoma of the liver.
        J Pediatr Surg. 2009; 44: 468-470
        • Meyers R.
        Tumors of the liver in children.
        Surg Oncol. 2007; 16: 195-203
        • Makin E.
        • Davenport M.
        Fetal and neonatal liver tumours.
        Early Hum Dev. 2010; 86: 637-642
        • Deutsch A.A.
        • Brown K.N.
        • Freeman N.V.
        • et al.
        A case of diaphragmatic hernia, absent pericardium and hamartoma of liver.
        Br J Surg. 1972; 59: 156-158
        • Lauwers G.Y.
        • Grant L.D.
        • Donnelly W.H.
        • et al.
        Hepatic undifferentiated (embryonal) sarcoma arising in a mesenchymal Hamartoma.
        Am J Surg Pathol. 1997; 21: 1248-1254
        • Bedii Salman A.
        Left sided congenital diaphragmatic hernia associated with intrathoracic ectopic liver lobule.
        Eur J Cardiothorac Surg. 2002; 21: 558-560
        • Beiler H.N.
        • Sergi C.
        • Wagner G.
        • et al.
        Accessory liver in an infant with congenital diaphragmatic hernia.
        J Pediatr Surg. 2001; 36: E7
        • Patel Y.
        • McNally J.
        • Ramani P.
        Left congenital diaphragmatic hernia, absent pericardium, and liver heterotopias: a case report and review.
        J Pediatr Surg. 2007; 42: 29-31