Abstract
Purpose
Some fetuses with sacrococcygeal teratoma (SCT) develop hydrops, but there is no consensus
on an appropriate prognostic marker for poor prognosis. The purpose of this study
is to establish predictors of poor prognosis in fetuses with SCT.
Methods
A retrospective review of patients with prenatally diagnosed SCT from 1986 to 2011
was performed. Patients with outcome data and ultrasound exams before 32 weeks gestational age (GA) were included (n = 37). Tumor volume-to-fetal weight ratio (TFR) and tumor morphology were assessed as
sonographic predictors of poor prognosis.
Results
Twelve patients (32%) had good prognosis, and twenty-five patients (68%) had poor
prognosis. All patients with poor prognosis had a morphology score ≥3, which is a significant predictor of poor prognosis (p <0.0001). TFR was assessed, and a receiver operating characteristic (ROC) analysis
identified a cutoff value of 0.12 before 24 weeks GA and 0.11 before 32 weeks GA as predictors for poor prognosis. TFR is a significant predictor of poor
prognosis (p < 0.0001).
Conclusions
Patients with cystic SCT all had good prognosis. TFR >0.12 was validated as a sonographic predictor of poor prognosis. TFR and tumor morphology
can be used to counsel expectant families with prenatally diagnosed SCT regarding
prognosis.
Key words
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Article info
Publication history
Accepted:
March 8,
2013
Received:
February 11,
2013
Identification
Copyright
© 2013 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
