Abstract
Purpose
Perianal perforating disease (PF) has been reported in approximately 15% of children
with Crohn’s disease (CD). It is unknown whether children who present with PF at the
time of diagnosis have a different course than those that develop PF while on therapy.
Methods
From a prospective, single institution observational registry of children diagnosed
with CD, we identified children with perianal perforating CD, defined as perianal
abscesses and/or fistulae. Patients who presented with perianal perforating CD (PF-CD0) were compared to those who developed perianal perforating CD (PF-CD1) after initial diagnosis.
Results
Thirty-eight of 215 (18%) children with CD had PF-CD during a median follow up of
4.5 years. Patients with PF-CD0 (n = 26) tended to be more likely male (81% vs. 50%, p = 0.07) and younger (9.3 yrs vs. 12.5 yrs, p = 0.02). PF-CD1 (n = 12) patients were more likely to require diverting ileostomy (42% vs. 8%, p = 0.02) and colectomy (33% vs. 4%, p = 0.03). Multivariable analysis predicted increased rate of diverting ileostomy in the
PF-CD1 group (p = 0.007, OR 19.1, 95% CI 1.6–234.8).
Conclusion
Pediatric CD patients who develop PF while on therapy for CD have a more severe phenotype
and are more likely to require diverting ileostomy or colectomy compared to those
who present with PF-CD.
Key words
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Article info
Publication history
Accepted:
March 8,
2013
Received:
February 23,
2013
Footnotes
☆Presented at the American Academy of Pediatrics National Conference in New Orleans, LA, October 2012.
Identification
Copyright
© 2013 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
