Abstract
Purpose
The effect of timing of onset of necrotizing enterocolitis (NEC) on outcomes has not
been determined for the full-term infant. In this study we aimed to characterize the
full-term NEC population and to evaluate onset of NEC.
Methods
We performed a two-center retrospective review of all full-term infants (≥ 37 weeks) with a diagnosis of NEC between 1990 and 2012. Patients were identified by
ICD-9 and age. Early onset for NEC was ≤7 days and late onset after 7 days of life. Demographics, comorbidities, maternal factors, clinical factors, surgical
intervention, complications, and mortality were evaluated. Wilcoxon’s test was performed
on continuous variables and Fisher’s exact test on categorical data. A p-value < 0.05 was considered significant. Univariate outcomes with a p-value < 0.1 were selected for multivariable analysis.
Results
Thirty-nine patients (24 boys, 15 girls) with median EGA of 39 weeks were identified. Overall mortality was 18%. Univariate predictors of mortality
included congenital heart disease and placement of an umbilical artery (UA) catheter.
Multivariate analysis revealed late onset of NEC to be an independent predictor of
mortality (OR 90.8, 95% CI 2.6–3121).
Conclusion
Full-term infants who develop NEC after 7 days of life, have congenital heart disease, and/or need UA catheterization have increased
mortality.
Key words
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Article info
Publication history
Published online: February 07, 2014
Accepted:
January 27,
2014
Received:
January 21,
2014
Identification
Copyright
© 2014 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
