Abstract
Background
Pathophysiology of appendicitis is associated with the underlying inflammatory processes.
Ethyl pyruvate (EP) has potent antioxidant and anti inflammatory properties. In this
study, we aimed to investigate the effects of EP on the treatment of appendicitis
and to examine whether adding EP to the antibiotic treatment could increases the effectiveness
of the treatment in a rat appendicitis model.
Method
Thirty two Wistar rats, which had previously created appendicitis, were randomly divided
into 4 groups: Group 1 (0.1 ml saline solution), Group 2 (15 mg/kg ceftriaxone), Group
3 (50 mg/kg EP), Group 4 (EP 50 mg/kg + ceftriaxone 15 mg/kg). In all groups, saline
solution, ceftriaxone and EP were administered intraperitoneally and the same procedure
was repeated twice a day for the following five days. On day 6, the rats underwent
relaparotomy and then intraabdominal findings were recorded. Histopathological examination
and interleukin 6 (IL 6) level were performed on appendiceal specimens.
Results
Intra abdominal adhesion score was significantly lower in Group 4 than in Group 1.
Total inflammation score was significantly lower in Group 2 than in Group 1 and was
significantly lower in Group 4 than in Group 3 and 1. IL 6 level was significantly
lower in Group 4 than in Group 3 and 1.
Conclusion
We found that adding EP to the antibiotic therapy increased the efficacy of the treatment
in the rat appendicitis model. Further studies are required to apply our findings
to the clinical setting.
Keywords
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Article info
Publication history
Published online: November 25, 2021
Accepted:
November 16,
2021
Received in revised form:
November 10,
2021
Received:
September 19,
2021
Identification
Copyright
© 2021 Elsevier Inc. All rights reserved.
