Abstract
Background
To explore the feasibility of micromagnetic ring in establishing biliary-enteric anastomosis
in a rat model.
Methods
A new micromagnetic ring suitable for rat biliary-enteric anastomosis model was designed
and fabricated. The common bile ducts of 20 Sprague-Dawley albino rats were ligated
and dilated after 2 weeks. Surgery for biliary-enteric anastomosis was completed by
using micromagnetic ring. The anastomosis time, postoperative survival rate, liver
function, liver histopathology, and complications were recorded. After 28 days, anastomotic
specimens were obtained to observe healing with the naked eye and light microscopy.
Results
Among the 20 Sprague-Dawley albino rats, one rat showed bile leakage and died one
week after ligation of the common bile duct and another rat was removed from the experiment
because there was no obvious dilatation of the common bile duct. The remaining 18
rats successfully underwent surgery for biliary-enteric anastomosis using micromagnetic
ring, with an average anastomosis time of 7.10 ± 1.15 min (range, 5.17–9.50 min).
The expulsion time of micromagnetic anastomosis rings was 11.94 ± 2.48 days (range,
8–17 days). The bilirubin level dropped to normal 1 week after surgery. Biliary-enteric
anastomotic specimens were obtained 28 days after surgery, and microscopic observation
showed that the mucosal layer of the anastomosis had good continuity and the anastomosis
was smooth.
Conclusion
A micromagnetic ring can be used to construct a rat biliary-enteric anastomosis model,
and it offers advantages, such as simple operation and reliable anastomosis effect.
Keywords
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Article info
Publication history
Published online: December 17, 2021
Accepted:
December 9,
2021
Received in revised form:
November 17,
2021
Received:
September 16,
2021
Identification
Copyright
© 2021 Elsevier Inc. All rights reserved.
