Abstract
Introduction
Lateral cervical lymph node metastases (LNM) for pediatric patients with papillary
thyroid cancer (PTC) is a poor prognostic factor. We aimed to identify risk factors
for lateral LNM.
Methods
This retrospective study had included 48 pediatric patients with papillary thyroid
cancer underwent total thyroidectomy and central cervical lymphadenectomy at K hospital
from 2016 to 2020.
Results
The number of patients in each T stage was as follows: 24 (50.0%) in stage 1, 9 (18.7%)
in Stage 2, 8 (16.7%) in Stage 3, and 7 (14.6%) in Stage 4. Most of the patients had
LNM with N1a and N1b rates of 83.3% and 62.5%, respectively. Lung metastases were
observed at presentation in three patients (6.3%). Univariate analysis revealed that
age (p = 0.021), male (p = 0.011), tumor size > 10 mm (p = 0.002), multifocality (p < 0.001), extrathyroidal extension (p = 0.001) and central LNM (p < 0.001) were factors that increase the risk of metastasis to lateral LNM.
Conclusion
Approximately 62.5% of pediatric patients with PTC exhibited lateral LNM at the time
of diagnosis. Our study confirmed that multifocality, maximum tumor diameter, extrathyroidal
extension and central LNM were independent risk factors for lateral LNM in pediatric
PTC.
Level of Evidence
Level IV.
Keywords
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Article info
Publication history
Published online: January 21, 2022
Accepted:
January 5,
2022
Received in revised form:
December 10,
2021
Received:
September 4,
2021
Identification
Copyright
© 2022 Published by Elsevier Inc.
