Advertisement

A potential clinical application of hydrogen-rich saline in patients with traumatic brain injury

      Owing to the possibility of potentially irreversible changes in personality, function, or sensation, traumatic brain injury (TBI) remains a feared complication of trauma. The downstream impacts of the damage can include loss of function, paralyzation, and reduced cognitive function. Death in these patients can occur suddenly, via immediate or delayed hemorrhage, or even owing to inflammation of the central nervous system which results in ischemia or necrosis. Despite the potentially devastating impact that TBI may present, current treatment methods around this condition are insufficient and are mostly centered around the management of the patient's presenting symptoms [
      • Borgen I.M.H.
      • Løvstad M.
      • Andelic N.
      • Hauger S.
      • Sigurdardottir S.
      • Søberg H.L.
      • et al.
      Traumatic brain injury – needs and treatment options in the chronic phase: study protocol for a randomized controlled community-based intervention.
      ]. For instance, mannitol or surgical procedures may be used to manage increased intracranial pressures as a result of the trauma.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Journal of Pediatric Surgery
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Borgen I.M.H.
        • Løvstad M.
        • Andelic N.
        • Hauger S.
        • Sigurdardottir S.
        • Søberg H.L.
        • et al.
        Traumatic brain injury – needs and treatment options in the chronic phase: study protocol for a randomized controlled community-based intervention.
        Trials. 2020; 21: 294https://doi.org/10.1186/s13063-020-4195-5
        • Hu Y.
        • Feng X.
        • Chen J.
        • Wu Y.
        • Shen L.
        Hydrogen-rich saline alleviates early brain injury through inhibition of necroptosis and neuroinflammation via the ROS/HO-1 signaling pathway after traumatic brain injury.
        Exp Ther Med. 2022; 23: 126https://doi.org/10.3892/etm.2021.11049
        • Ji X.
        • Tian Y.
        • Xie K.
        • Liu W.
        • Qu Y.
        • Fei Z.
        Protective effects of hydrogen-rich saline in a rat model of traumatic brain injury via reducing oxidative stress.
        J Surg Res. 2012; 178: e9-16https://doi.org/10.1016/j.jss.2011.12.038
        • Shen L.
        • Wang J.
        • Liu K.
        • Wang C.
        • Wang C.
        • Wu H.
        • et al.
        Hydrogen-rich saline is cerebroprotective in a rat model of deep hypothermic circulatory arrest.
        Neurochem Res. 2011; 36: 1501-1511https://doi.org/10.1007/s11064-011-0476-4
        • Bracken M.B.
        Why animal studies are often poor predictors of human reactions to exposure.
        J R Soc Med. 2009; 102: 120-122https://doi.org/10.1258/jrsm.2008.08k033