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How to deal with rare pediatric surgical diseases in the small developing country with limited resources: Insights from Bosnia and Herzegovina

      The European Union Regulation on Orphan Medicinal Products defines a disease/condition as rare if it affects < 1 in 2.000 in the European population [

      Regulation (EC) No 141/2000 of the European Parliament and of the Council of 16 December 1999 on orphan medicinal products. 2000. Off J Eur Union L018. 2000:0001-5.

      ], making the prevalence data a key tool in creating health care policies for patients with rare diseases (RD) [
      • Shourick J.
      • Wack M.
      • Jannot A.S.
      Assessing rare diseases prevalence using literature quantification.
      ]. There is approximately 7.000 RD, mainly genetic [
      • Boycott K.M.
      • Rath A.
      • Chong J.X.
      • Hartley T.
      • Alkuraya F.S.
      • Baynam G.
      • et al.
      International cooperation to enable the diagnosis of all rare genetic diseases.
      ], affecting approximately 30 million people in Europe and between 25 and 30 million in the United States [
      • Zurynski Y.
      • Frith K.
      • Leonard H.
      • Elliott E.
      Rare childhood diseases: how should we respond?.
      ].
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      References

      1. Regulation (EC) No 141/2000 of the European Parliament and of the Council of 16 December 1999 on orphan medicinal products. 2000. Off J Eur Union L018. 2000:0001-5.

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