Advertisement

Clinical and surgical outcome differences on the basis of pathology category in cervical neuroblastic tumors

  • Qiaoyin Liu
    Footnotes
    Affiliations
    Department of Otorhinolaryngology, Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China
    Search for articles by this author
  • Shengcai Wang
    Footnotes
    Affiliations
    Department of Otorhinolaryngology, Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China
    Search for articles by this author
  • Ping Chu
    Affiliations
    Beijing Key Laboratory for Pediatric Diseases of Otolaryngology Head and Neck Surgery, Beijing Pediatric Research Institute, Capital Medical University, National Center for Children's Health, Beijing, China
    Search for articles by this author
  • Jihang Sun
    Affiliations
    Imaging center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China
    Search for articles by this author
  • Yaqiong Jin
    Affiliations
    Beijing Key Laboratory for Pediatric Diseases of Otolaryngology Head and Neck Surgery, Beijing Pediatric Research Institute, Capital Medical University, National Center for Children's Health, Beijing, China
    Search for articles by this author
  • Yongli Guo
    Affiliations
    Beijing Key Laboratory for Pediatric Diseases of Otolaryngology Head and Neck Surgery, Beijing Pediatric Research Institute, Capital Medical University, National Center for Children's Health, Beijing, China
    Search for articles by this author
  • Xiaoli Ma
    Affiliations
    Hematology Oncology Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China
    Search for articles by this author
  • Lejian He
    Affiliations
    Department of Pathology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China
    Search for articles by this author
  • Yan Su
    Affiliations
    Hematology Oncology Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China
    Search for articles by this author
  • Jie Zhang
    Affiliations
    Department of Otorhinolaryngology, Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China
    Search for articles by this author
  • Yun Peng
    Affiliations
    Imaging center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China
    Search for articles by this author
  • Yanzhen Li
    Affiliations
    Department of Otorhinolaryngology, Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China
    Search for articles by this author
  • Xuexi Zhang
    Affiliations
    Department of Otorhinolaryngology, Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China
    Search for articles by this author
  • Nian Sun
    Affiliations
    Department of Otorhinolaryngology, Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China
    Search for articles by this author
  • Zhiyong Liu
    Affiliations
    Department of Otorhinolaryngology, Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China
    Search for articles by this author
  • Xin Ni
    Correspondence
    Corresponding author.
    Affiliations
    Department of Otorhinolaryngology, Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China
    Search for articles by this author
  • Author Footnotes
    1 These authors contributed equally to this work.

      Abstract

      Background

      : Cervical neuroblastic tumors (NTs) are rare but less aggressive cancer with an above-average survival rate. Little has been published regarding the management and surgical outcomes of patients with cervical NTs based on pathology category. This study compared and identified the preoperative characteristics of cervical NTs in different pathology categories and evaluated the outcomes of patients undergoing surgical resection.

      Materials and methods

      : Upon the institutional review board's approval, a retrospective chart review was performed at Beijing Children's Hospital from April 2013 to August 2020. Demographics of patients, imaging data, lab test results, operation details and outcomes were recorded and analyzed.

      Results

      : Of 32 cervical NTs, 24(80%) were classified as neuroblastoma (NB) /ganglioneuroblastoma-nodular (GNBn) and 8(20%) as ganglioneuroblastoma-intermixed (GNBi)/ ganglioneuroma (GN). Patients with GNBi/GN were older than those with NB/GNBn (44.5 months (IQR 16–81) vs 9 months (IQR 1–47); P = 0.001). GNBi/GN patients presented more frequently with stage 1 disease compared with NB/GNBn patients (100% vs. 29.2%, P = 0.001), less frequently with tumor-related symptoms (0% vs. 70.8%, P = 0.001), artery encased tumor (0% vs. 41.7%, P = 0.035), and surgical complications (25% vs. 70.8%, P = 0.038). GNBi/GN patients were also less likely to show elevated neuron specific enolase (NSE) (12.5% vs. 79.2%, P = 0.002).

      Conclusions

      : Cervical NB/GNBn and GNBi/GN patients had distinct characteristic clinical presentations and surgical outcomes. For children with features suggestive of benign disease (older age, asymptomatic, normal serum tumor markers) and no artery image-defined risk factors (IDRFs), upfront resection can be considered.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Journal of Pediatric Surgery
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Shimada H.
        • Ambros I.M.
        • Dehner L.P.
        • Hata J.
        • Joshi V.V.
        • Roald B.
        Terminology and morphologic criteria of neuroblastic tumors: recommendations by the international neuroblastoma pathology committee.
        Cancer. 1999; 86: 349e363
        • Berthold F.
        • Spix C.
        • Kaatsch P.
        • Lampert F.
        Incidence, survival, and treatment of localized and metastatic neuroblastoma in Germany 1979–2015.
        Paediatr Drugs. 2017; 19: 577e593
        • Salim A.
        • Raitio A.
        • Barry P.
        • et al.
        Neuroblastoma: the association of anatomical tumour site, molecular biology and patient outcomes.
        ANZ J Surg. 2021; 91: 1000-1004
        • Vo KT
        • Matthay KK
        • et al.
        Clinical, biologic, and prognostic differences on the basis of primary tumor site in neuroblastoma: a report from the international neuroblastoma risk group project.
        J Clin Oncol: Off J Am Soc Clin Oncol. 2014; 32 (Oct 01): 3169-3176
        • Decarolis B.
        • Simon T.
        • Krug B.
        • et al.
        Treatment and outcome of ganglioneuroma and ganglioneuroblastoma intermixed.
        BMC Cancer. 2016; 16: 542
        • Cohn SL
        • Pearson AD J
        • et al.
        The International Neuroblastoma Risk Group (INRG) classification system: an INRG task force report.
        J Clin Oncol: Off J Am Soc Clin Oncol. 2009; 27 (Jan 10): 289-297
        • Okamatsu C.
        • London W.B.
        • Naranjo A.
        • Hogarty M.D.
        • Gastier-Foster J.M.
        • Look A.T.
        • et al.
        Clinicopathological characteristics of ganglioneuroma and ganglioneuroblastoma: a report from the CCG and COG.
        Pediatr Blood Cancer. 2009; 53: 563-569
        • Irwin MS
        • Naranjo A
        • et al.
        Revised neuroblastoma risk classification system: a report from the children's oncology group.
        J Clin Oncol: Off J Am Soc Clin Oncol. 2021; 39: 3229-3241
        • Angelini P.
        • London W.B.
        • Cohn S.L.
        • et al.
        Characteristics and outcome of patients with ganglioneuroblastoma, nodular subtype: a report from the INRG projec.
        Eur J Cancer. 2012; 48: 1185-1191
        • Matthay K.K.
        • Maris J.M.
        • Schleiermacher G.
        • et al.
        Neuroblastoma.
        Nat Rev Dis Primers. 2016; 11 (2): 16078
        • Yang S
        • Cai S
        • et al.
        Discrimination of histopathologic types of childhood peripheral neuroblastic tumors based on clinical and biological factors.
        Sci Rep. 2018; 8 (Jul 19): 10924
        • Alexander N.
        • Sullivan K.
        • Shaikh F.
        • et al.
        Characteristics and management of ganglioneuroma and ganglioneuroblastoma-intermixed in children and adolescents.
        Pediatr Blood Cancer. 2018; 65 (05): e26964
        • Jackson JR
        • Tran HC
        • et al.
        The clinical management and outcomes of cervical neuroblastic tumors.
        J Surg Res. 2016; 204 (07): 109-113
        • Qureshi S.S.
        • Kembhavi S.
        • Ramadwar M.
        • et al.
        Outcome and morbidity of surgical resection of primary cervical and cervicothoracic neuroblastoma in children: a comparative analysis.
        Pediatr Surg Int. 2014; 30: 267-273
        • Brisse HJ
        • McCarville M B
        • et al.
        International neuroblastoma risk group project; guidelines for imaging and staging of neuroblastic tumors: consensus report from the international neuroblastoma risk group project.
        Radiology. 2011; 261 (Oct): 243-257
        • Brodeur G.M.
        • Pritchard J.
        • Berthold F.
        • et al.
        Revisions of the international criteria for neuroblastoma diagnosis, staging, and response to treatment.
        J Clin Oncol. 1993; 11: 1466e1477
        • Su Y.
        • Qin H.
        • Chen C.
        • et al.
        Treatment and outcomes of 1041 pediatric patients with neuroblastoma who received multidisciplinary care in China.
        Pediatr Iinvestig. 2020; 4 (Sep): 157-167
        • Braungart S.
        • Craigie R.J.
        • Farrelly P.
        • et al.
        Paediatric Horner's syndrome: is investigation for underlying malignancy always required?.
        Arch Dis Child. 2019; 104 (10): 984-987
        • Lonergan G.J.
        • Schwab C.M.
        • Suarez E.S.
        • et al.
        Neuroblastoma, ganglioneuroblastoma, and ganglioneuroma: radiologic-pathologic correlation.
        Radiogr Rev Publ Radiol Soc N Am, Inc. 2002; 22: 911
        • Temple WC
        • Vo KT
        • Matthay KK
        • et al.
        Association of image-defined risk factors with clinical features, histopathology, and outcomes in neuroblastoma.
        Cancer Med. 2021; 10 (04): 2232-2241
        • Bernardi B.D.
        • Gambini C.
        • Haupt R.
        • et al.
        Retrospective study of childhood ganglioneuroma.
        J Clin Oncol: Off J Am Soc Clin Oncol. 2008; 26: 1710-1716
        • Caroline C.S.
        • Meryle J.E.
        • Jacqueline M.K.
        • et al.
        Updates in diagnosis, management, and treatment of neuroblastoma.
        Radiogr Rev Publ Radiol Soc N Am Inc. 2018; 38 (Mar-Apr): 566-580
        • Haddad M.
        • Triglia J.M.
        • Helardot P.
        • et al.
        Localized cervical neuroblastoma: prevention of surgical complications.
        Int J Pediatr Otorhinolaryngol. 2004; 67: 1361-1367
        • Sosnowska-Sienkiewicz P.
        • Januszkiewicz-Lewandowska D.
        • Losin M.
        • et al.
        Arterial constriction after resection of neuroblastic tumors in children: two-center retrospective study[J].
        J Pediatr Surg. 2021; 56 (Sep): 1661-1667
        • Peuchmaur M.
        • D"Amore E.S.G.
        • Joshi V.V.
        • et al.
        Revision of the international neuroblastoma pathology classification: confirmation of favorable and unfavorable prognostic subsets in ganglioneuroblastoma, nodular.
        Cancer. 2003; 98: 2274-2281
        • Whitlock R.S.
        • Mehl S.C.
        • Larson S.K.
        • et al.
        Characteristics of benign neuroblastic tumors: is surgery always necessary?.
        J Pediatr Surg. 2021; 57: 1538-1543