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Early Growth and Body Composition Assessed by Air Displacement Plethysmography in Infants Born with Simple Gastroschisis

Published:November 23, 2022DOI:https://doi.org/10.1016/j.jpedsurg.2022.11.005

      Abstract

      Background

      Gastroschisis is an abdominal wall malformation usually associated with impaired growth.

      Objective

      To evaluate the growth and body composition of infants born with simple gastroschisis in a referral center.

      Methods

      This was a single-center, prospective case series of infants with simple gastroschisis who were measured at birth, at discharge, and at 3 months. Body composition was assessed via air-displacement plethysmography at discharge and at 3 months. The results were compared with those reported for healthy infants at an equivalent gestational age.

      Results

      Simple gastroschisis infants were lighter and smaller at birth and remained similar at 3 months. All anthropometric z scores decreased from birth to discharge, followed by an increase but not a full recovery toward 3 months. Overall, gastroschisis infants had a similar FM percentage, FM% (11.1 ± 4.7), but a lower FFM, FFM (2,481 ± 478 g), at discharge. FM% (18.5 ± 5.3) decreased at 3 months, and FFM remained lower (3,788 ± 722 g) but improved between the two exams. Boys had significantly more FFM than girls at both evaluations. The multiple regression analysis showed that male sex, prematurity, total parenteral nutrition duration, and exclusive breast milk diets were associated with differences in body composition.

      Conclusions

      Infants with simple gastroschisis cared for in a referral center experienced growth failure at discharge and showed a similar FM% but lower FFM than healthy infants. At 3 months, they exhibited smaller FM% and FFM, but FFM improved after the first exam, representing a better protein accretion.

      Type of study

      Prognostic

      Level of evidence

      IV

      Keywords

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