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Research Article| Volume 58, ISSUE 4, P608-612, April 2023

Cost and outcomes of intercostal nerve cryoablation versus thoracic epidural following the Nuss procedure

Published:December 22, 2022DOI:https://doi.org/10.1016/j.jpedsurg.2022.12.011

      Highlights

      • Pain control is the main issue in the postoperative course of patients undergoing the Nuss procedure for pectus excavatum.
      • Compared to thoracic epidural, intercostal nerve cryoablation was associated with lower opioid use and shorter length of stay.
      • Intercostal nerve cryoablation is associated with increased operative time and increased hospitalization cost.

      Summary

      Background

      Pectus excavatum is the most common congenital chest wall abnormality, with the Nuss procedure being the most commonly performed repair. Pain control is the predominant factor in the postoperative treatment of these patients. This study aims to compare the cost and outcomes of intercostal nerve cryoablation (INC) and thoracic epidural (TE) in patients undergoing the Nuss procedure.

      Methods

      A retrospective chart review was conducted at our institution for all patients who underwent the Nuss procedure for pectus excavatum from 2002 to 2020. Patients were stratified by pain management strategy, INC vs. TE. Chi-square and Fisher's exact were used to compare categorical variables. Wilcoxon tests were used to evaluate continuous variables and costs.

      Results

      A total of 158 patients were identified. Of these, 80.4% (N = 127) were treated with epidural, while 19.6% (N = 31) were treated with intercostal nerve cryoablation. The INC group had lower rates of PCA use (35.5% vs. 93.7%, p < 0.001), lower total morphine milligram equivalent requirement (27.0 vs. 290.8, p < 0.001), and shorter length of stay (3.2 days vs. 5.3 days, p < 0.001) compared to the TE group. INC was also associated with longer operative times (153.0 min vs. 89.0 min, p < 0.001). The total hospitalization cost for the INC group was higher compared to the TE group ($24,742.5 vs $21,621.9, p = 0.001).

      Conclusions

      In patients undergoing the Nuss procedure, compared to thoracic epidural, INC was associated with lower opioid use and shorter length of stay but at the cost of longer operative time and increased hospitalization cost.

      Level of evidence

      Treatment Study, Level III.

      Keywords

      Abbreviations:

      BMI (Body Mass Index), IQR (Interquartile Range), INC (Intercostal Nerve Cryoablation), MME (Morphine Milligram Equivalent), PCA (Patient Controlled Analgesia), TE (Thoracic epidural)
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      References

        • Jaroszewski D.
        • Notrica D.
        • McMahon L.
        • Steidley D.E.
        • Deschamps C.
        Current management of pectus excavatum: a review and update of therapy and treatment recommendations.
        J Am Board Fam Med. 2010; 23: 230-239
        • Fokin A.A.
        • Steuerwald N.M.
        • Ahrens W.A.
        • Allen K.E.
        Anatomical, histologic, and genetic characteristics of congenital chest wall deformities.
        Semin Thorac Cardiovasc Surg. 2009; 21: 44-57
        • Nuss D.
        • Obermeyer R.J.
        • Kelly R.E.
        Nuss bar procedure: past, present and future.
        Ann Cardiothorac Surg. 2016; 5: 422-433
        • Mao Y.Z.
        • Tang S.
        • Li S.
        Comparison of the Nuss versus Ravitch procedure for pectus excavatum repair: an updated meta-analysis.
        J Pediatr Surg. 2017; 52: 1545-1552
        • Fraser J.A.
        • Briggs K.B.
        • Svetanoff W.J.
        • Aguayo P.
        • Juang D.
        • Fraser J.D.
        • et al.
        Short and long term outcomes of using cryoablation for postoperative pain control in patients after pectus excavatum repair.
        J Pediatr Surg. 2022; 57: 1050-1055
        • Keller B.A.
        • Kabagambe S.K.
        • Becker J.C.
        • Chen Y.J.
        • Goodman L.F.
        • Clark-Wronski J.M.
        • et al.
        Intercostal nerve cryoablation versus thoracic epidural catheters for postoperative analgesia following pectus excavatum repair: preliminary outcomes in twenty-six cryoablation patients.
        J Pediatr Surg. 2016; 51: 2033-2038
        • Clark R.A.
        • Jacobson J.C.
        • Singhal A.
        • Alder A.C.
        • Chung D.H.
        • Pandya S.R.
        Impact of cryoablation on pectus excavatum repair in pediatric patients.
        J Am Coll Surg. 2022; 234: 484-492
        • Graves C.E.
        • Moyer J.
        • Zobel M.J.
        • Mora R.
        • Smith D.
        • O'Day M.
        • et al.
        Intraoperative intercostal nerve cryoablation during the Nuss procedure reduces length of stay and opioid requirement: a randomized clinical trial.
        J Pediatr Surg. 2019; 54: 2250-2256
        • Harbaugh C.M.
        • Johnson K.N.
        • Kein C.E.
        • Jarboe M.D.
        • Hirschl R.B.
        • Geiger J.D.
        • et al.
        Comparing outcomes with thoracic epidural and intercostal nerve cryoablation after Nuss procedure.
        J Surg Res. 2018; 231: 217-223
        • Sujka J.
        • Benedict L.A.
        • Fraser J.D.
        • Aguayo P.
        • Millspaugh D.L.
        • St Peter S.D.
        Outcomes using cryoablation for postoperative pain control in children following minimally invasive pectus excavatum repair.
        J Laparoendosc Adv Surg Tech. 2018; 28: 1383-1386
        • Sun R.C.
        • Mehl S.C.
        • Anbarasu C.R.
        • Portuondo J.I.
        • Espinoza A.F.
        • Whitlock R.
        • et al.
        Intercostal cryoablation during Nuss procedure: a large volume single surgeon's experience and outcomes.
        J Pediatr Surg. 2021; 56: 2229-2234
        • Bryan M.F.
        • Cecchetti S.G.
        The consumer price index as a measure of inflation.
        National Bureau of Economic Research Cambridge, Mass., USA1993
        • Chumpitazi C.E.
        • Rees C.A.
        • Camp E.A.
        • Bernhardt M.B.
        Decreased opioid prescribing in a pediatric emergency department after the rescheduling of hydrocodone.
        J Emerg Med. 2017; 52: 547-553
        • McCabe S.E.
        • West B.T.
        • Veliz P.
        • McCabe V.V.
        • Stoddard S.A.
        • Boyd C.J.
        Trends in medical and nonmedical use of prescription opioids among US adolescents: 1976-2015.
        Pediatrics. 2017; 139
        • Groenewald C.B.
        Opioid-prescribing patterns for pediatric patients in the United States.
        Clin J Pain. 2019; 35: 515-520
        • Ferland C.E.
        • Vega E.
        • Ingelmo P.M.
        Acute pain management in children: challenges and recent improvements.
        Current Opinion in Anesthesiology. 2018; 31: 327-332
        • Harbaugh C.M.
        • Gadepalli S.K.
        Pediatric postoperative opioid prescribing and the opioid crisis.
        Curr Opin Pediatr. 2019; 31: 378-385
        • DiFiore J.W.
        • Robertson J.O.
        • Chhabada S.
        • DeRoss A.L.
        • Hossain M.S.
        • Rincon-Cruz L.
        • et al.
        Next day discharge after the Nuss procedure using intercostal nerve cryoablation, intercostal nerve blocks, and a perioperative ERAS pain protocol.
        J Pediatr Surg. 2022; 57: 213-218
        • Aiken T.J.
        • Stahl C.C.
        • Lemaster D.
        • Casias T.W.
        • Walker B.J.
        • Nichol P.F.
        • et al.
        Intercostal nerve cryoablation is associated with lower hospital cost during minimally invasive Nuss procedure for pectus excavatum.
        J Pediatr Surg. 2021; 56: 1841-1845
        • Rettig R.L.
        • Rudikoff A.G.
        • Lo H.Y.A.
        • Shaul D.B.
        • Banzali F.M.
        • Conte A.H.
        • et al.
        Cryoablation is associated with shorter length of stay and reduced opioid use in pectus excavatum repair.
        Pediatr Surg Int. 2021; 37: 67-75