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Serum alpha-fetoprotein (AFP) values in 61 infants and children with mature, immature,
or malignant teratoma were analyzed in comparison with the normal ranges of AFP. AFP
was within the normal ranges in 23 of 24 mature teratomas, and higher than the upper
border of the normal ranges in 31 of 32 malignant teratomas. The number of immature
teratomas studied here was very small. These results suggest that the diagnostic value
of AFP would seem very high even in infancy and childhood, if data are compared with
the normal ranges. This conclusion appears particularly noticeable because the authors
had once made a preliminary report on this subject in which they concluded that the
differentiation between benign and malignant teratoma by AFP would be impossible under
the age of 2 mo.
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References
- Endodermal sinus tumor of the ovary and testis.Cancer. 1959; 12: 1092-1105
- The clinical use of AFP and HCG in testicular tumors of germ cell origin.Lancet. 1978; 2: 1042
- A study on alpha-fetoprotein and endodermal sinus tumor.J Pediatr Surg. 1975; 10: 501-506
- Benign and malignant teratomas in children: Analysis of 85 patients.Surgery. 1976; 80: 297-305
- Endodermal sinus (yolk sac) tumors in infants and children.J Pediatr Surg. 1979; 14: 520-524
- Evaluation of alpha-fetoprotein in early infancy.J Pediatr Surg. 1978; 13: 155-156
Endo Y: Personal communication, 1979
- Synthesis of alphafetoprotein by liver, yolk sac and gastrointestinal tract of the human conceptus.Cancer Res. 1972; 32: 979-982
Article info
Footnotes
*Supported in part by a Cancer Research Grant from the Ministry of Health and Welfare, and a Grant in Aid for Scientific Research from the Ministry of Education, Science, and Culture of the Government of Japan.
Identification
Copyright
© 1983 Grune & Stratton, Inc. Published by Elsevier Inc.
