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The relationship between Helicobacter pylori infection and acid-hematuria syndrome in pediatric patients with gastric augmentation-II

  • Sinan Celayir
    Affiliations
    Section of Pediatric Urology, Department of Pediatric Surgery, Cerrahpaşa Medical Faculty, University of Istanbul, Istanbul, Turkey.

    Department of Pathology, Cerrahpa¢a Medical Faculty, University of Istanbul, Istanbul, Turkey.
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  • Suha Göksel
    Affiliations
    Section of Pediatric Urology, Department of Pediatric Surgery, Cerrahpaşa Medical Faculty, University of Istanbul, Istanbul, Turkey.

    Department of Pathology, Cerrahpa¢a Medical Faculty, University of Istanbul, Istanbul, Turkey.
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  • S.N.Cenk Büyükünal
    Correspondence
    Address reprint requests to S.N. Cenk Büyükünal, MD, Haciemin Sok. Ersek Apt. No: 30–32, D-3 80200 Nişantaşt, Istanbul, Turkey.
    Affiliations
    Section of Pediatric Urology, Department of Pediatric Surgery, Cerrahpaşa Medical Faculty, University of Istanbul, Istanbul, Turkey.

    Department of Pathology, Cerrahpa¢a Medical Faculty, University of Istanbul, Istanbul, Turkey.
    Search for articles by this author
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      Abstract

      Background/Purpose: The acid-hematuria syndrome, which presents with dysuria, hematuria, and perineal pain still remains a problem in those patients who have undergone bladder augmentation using the gastrocystoplasty technique. Additionally, there is still a question regarding the explanation for postoperative metabolic problems such as metabolic alkalosis, hypocholoremia, hypergastrinemia, and various complications related to gastritis and peptic ulcer disease. The aim of this study was to investigate the relation of Helicobacter pylori (HP) infection in this patient group and the relationship between HP infection and the abovementioned clinical problems and complications.
      Methods: In this study, 10 children with a history of previous gastrocystoplasty (five girls, five boys; mean age, 6.75 ± 2.53 years; range, 2.5 to 12 years) were evaluated. Blood samples for HP detection were analyzed by serological testing (ELISA technique). Histopathologic studies were performed for gastric tissue specimens, obtained by endoscopic procedures from the stomach and augmented bladder. Urine pH and serum gastrin levels were measured in all patients.
      Results: Regarding the serological studies, four of ten patients had a positive ELISA test result (40%). The four patients with HP-positive serological test results, were the patients who had acid-hematuria syndrome. These patients also had low urine pH levels (mean, 4.5) when compared with those of HP-negative patients. HP-positive patients also had high serum gastrin levels in comparison with those of HP-negative patients.
      Conclusions: The relation between HP infection and problems such as hypergastrinemia, acid output, and ulcer disease is well known. Our study demonstrates a correlation between the HP-positive gastrocystoplasty patients and the above-mentioned symptoms and complications. Because of the potential risk of HP infection, we suggest that HP infection be investigated in patients with gastrocystoplasty or in candidates for a gastrocystoplasty operation. HP-positive patients should be treated, to reduce the risks of postoperative complications.

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      References

        • Rowland M
        • Drumm B
        Helicobacter pylori infection and peptic ulcer disease in children.
        Curr Opin Pediatrics. 1995; 7: 553-559
        • Kilbridge PM
        • Dahms BB
        • Czinn SJ
        Campylobacter pyloriassociated gastritis and peptic ulcer disease in children.
        Am J Dis Child. 1988; 142: 1149-1152
        • Nguyen DH
        • Mitchell ME
        Gastric bladder reconstruction. Partial and total bladder reconstruction.
        Urol Clin North Am. 1991; 118: 649-657
        • Plawker MW
        • Rabinowitz SS
        • Etwardu DJ
        • et al.
        Hypergastrinemia, dysuria-hematuria and metabolic alkalosis: Complications associated with gastrocystoplasty.
        J Urol. 1995; 154: 546-549
        • Sheldon CA
        • Gilbert A
        • Wacksman J
        • et al.
        Gastrocystoplasty: Technical and metabolic characteristics of the most versatile childhood bladder augmentation modality.
        J Pediatr Surg. 1995; 30: 283-288
        • Celayir S
        • Göksel S
        • Ünal T
        • et al.
        Helicobacter pylori infection in a child with gastric augmentation.
        J Pediatr Surg. 1997; 32: 1757-1758
        • Bogaert GA
        • Mevorach RA
        • Kim J
        • et al.
        The physiology of gastrocystoplasty: Once a stomach, always a stomach.
        J Urol. 1995; 153: 1977-1980
        • Marshall BJ
        Helicobacter Pylori.
        Am J Gastroenterol. 1994; 89: 116-127
        • Ferris DO
        • Odel HM
        Electrolyte pattern of the blood after bilateral ureterosigmoidostomy.
        JAMA. 1950; 142: 634
        • Steiner MS
        • Morton RA
        Nutritional and gastrointestinal complications of the use of bowel segments in the lower urinary tract. Partial and total bladder reconstruction.
        Urol Clin North Am. 1991; 18: 743-754
        • Treiger BFG
        • Marshall FF
        Carcinogenesis and the use of intestinal segments in the urinary tract. Partial and total bladder reconstruction.
        Urol Clin North Am. 1991; 18: 737-742
        • Peura DA
        Helicobacter pylori and ulcerogenesis.
        Am J Med. 1996; 100: 19S-26S
        • Nguyen DH
        • Bain MA
        • Salmonson KL
        • et al.
        The syndrome of dysuria and hematuria in pediatric urinary reconstruction with stomach.
        J Urol. 1993; 150: 707-709
        • Lim STK
        • Lam SK
        • Lee NW
        • et al.
        Effects of gastrocystoplasty on serum gastrin levels and gastric acid secretion.
        Br J Surg. 1983; 70: 275-277
        • The Eurogast Study Group
        An international association between Helicobacter pylori infection and gastric cancer.
        Lancet. 1993; 341: 1359-1362
        • Bogaert GA
        • Mevorach RA
        • Kogan BA
        Urodynamics and clinical follow-up of 28 children after gastrocystoplasty.
        Br J Urol. 1994; 74: 469-475
        • Talley NJ
        • Zinsmeister AR
        • Weaver A
        • et al.
        Gastric adenocarcinoma and Helicobacter pylori infection.
        J Natl Cancer Inst. 1991; 83: 1734-1739