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Abstract
Background/Purpose: The acid-hematuria syndrome, which presents with dysuria, hematuria, and perineal
pain still remains a problem in those patients who have undergone bladder augmentation
using the gastrocystoplasty technique. Additionally, there is still a question regarding
the explanation for postoperative metabolic problems such as metabolic alkalosis,
hypocholoremia, hypergastrinemia, and various complications related to gastritis and
peptic ulcer disease. The aim of this study was to investigate the relation of Helicobacter pylori (HP) infection in this patient group and the relationship between HP infection and
the abovementioned clinical problems and complications.
Methods: In this study, 10 children with a history of previous gastrocystoplasty (five girls,
five boys; mean age, 6.75 ± 2.53 years; range, 2.5 to 12 years) were evaluated. Blood
samples for HP detection were analyzed by serological testing (ELISA technique). Histopathologic
studies were performed for gastric tissue specimens, obtained by endoscopic procedures
from the stomach and augmented bladder. Urine pH and serum gastrin levels were measured
in all patients.
Results: Regarding the serological studies, four of ten patients had a positive ELISA test
result (40%). The four patients with HP-positive serological test results, were the
patients who had acid-hematuria syndrome. These patients also had low urine pH levels
(mean, 4.5) when compared with those of HP-negative patients. HP-positive patients
also had high serum gastrin levels in comparison with those of HP-negative patients.
Conclusions: The relation between HP infection and problems such as hypergastrinemia, acid output,
and ulcer disease is well known. Our study demonstrates a correlation between the
HP-positive gastrocystoplasty patients and the above-mentioned symptoms and complications.
Because of the potential risk of HP infection, we suggest that HP infection be investigated
in patients with gastrocystoplasty or in candidates for a gastrocystoplasty operation.
HP-positive patients should be treated, to reduce the risks of postoperative complications.
Keywords
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© 1999 Published by Elsevier Inc.
